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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Golgb1em8Lanyu
endonuclease-mediated mutation 8, Yu Lan
MGI:6149910
Summary 4 genotypes


Genotype
MGI:6151466
hm1
Allelic
Composition		 Golgb1em8Lanyu/Golgb1em8Lanyu
Genetic
Background		 FVB/NJ-Golgb1em8Lanyu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Golgb1em8Lanyu mutation (0 available); any Golgb1 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:235669 )
N
• palatal shelves shape and size like controls up to E13.5
abnormal palate development ( J:235669 )
• smaller palatal shelves than controls after E13.5, with higher cellular density throughout anterior-posterior axis
• less Alcian Blue staining in palatal mesenchyme after E13.5
• reduced hyaluronan (HA) accumulation throughout anterior-posterior axis of palatal mesenchyme at E13.5
• reduced hyaluronan (HA) accumulation in hinge region and at nasal side of palatal mesenchyme at E13.5
palatal shelves fail to meet at midline ( J:235669 )
• un-fused palatal shelves in E15.5 and E16.5 embryos
decreased palatal shelf size ( J:235669 )
• smaller palatal shelves than controls after E13.5
cleft palate ( J:235669 )
• vertically oriented un-fused palatal shelves in E15.5 and E16.5 embryos
failure of palatal shelf elevation ( J:235669 )
• vertically oriented un-fused palatal shelves in E15.5 and E16.5 embryos
abnormal tongue position ( J:235669 )
• failure of tongue to descend to oral cavity floor in E14.5-16.5 embryos

digestive/alimentary system
abnormal palate development ( J:235669 )
• smaller palatal shelves than controls after E13.5, with higher cellular density throughout anterior-posterior axis
• less Alcian Blue staining in palatal mesenchyme after E13.5
• reduced hyaluronan (HA) accumulation throughout anterior-posterior axis of palatal mesenchyme at E13.5
• reduced hyaluronan (HA) accumulation in hinge region and at nasal side of palatal mesenchyme at E13.5
palatal shelves fail to meet at midline ( J:235669 )
• un-fused palatal shelves in E15.5 and E16.5 embryos
decreased palatal shelf size ( J:235669 )
• smaller palatal shelves than controls after E13.5
cleft palate ( J:235669 )
• vertically oriented un-fused palatal shelves in E15.5 and E16.5 embryos
failure of palatal shelf elevation ( J:235669 )
• vertically oriented un-fused palatal shelves in E15.5 and E16.5 embryos
abnormal tongue position ( J:235669 )
• failure of tongue to descend to oral cavity floor in E14.5-16.5 embryos

growth/size/body
abnormal palate development ( J:235669 )
• smaller palatal shelves than controls after E13.5, with higher cellular density throughout anterior-posterior axis
• less Alcian Blue staining in palatal mesenchyme after E13.5
• reduced hyaluronan (HA) accumulation throughout anterior-posterior axis of palatal mesenchyme at E13.5
• reduced hyaluronan (HA) accumulation in hinge region and at nasal side of palatal mesenchyme at E13.5
palatal shelves fail to meet at midline ( J:235669 )
• un-fused palatal shelves in E15.5 and E16.5 embryos
decreased palatal shelf size ( J:235669 )
• smaller palatal shelves than controls after E13.5
cleft palate ( J:235669 )
• vertically oriented un-fused palatal shelves in E15.5 and E16.5 embryos
failure of palatal shelf elevation ( J:235669 )
• vertically oriented un-fused palatal shelves in E15.5 and E16.5 embryos
abnormal tongue position ( J:235669 )
• failure of tongue to descend to oral cavity floor in E14.5-16.5 embryos

homeostasis/metabolism
decreased hyaluronic acid level ( J:235669 )
• reduced hyaluronan (HA) accumulation throughout anterior-posterior axis of palatal mesenchyme at E13.5
• reduced HA accumulation in hinge region and at nasal side of palatal mesenchyme at E13.5

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
cleft palate DOID:674 J:235669




Genotype
MGI:6151468
ht2
Allelic
Composition		 Golgb1em8Lanyu/Golgb1em33Lanyu
Genetic
Background		 FVB/NJ-Golgb1em8Lanyu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Golgb1em33Lanyu mutation (1 available); any Golgb1 mutation (117 available)
Golgb1em8Lanyu mutation (0 available); any Golgb1 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
failure of palatal shelf elevation ( J:235669 )
• vertically oriented un-fused palatal shelves in maxillary explants from E13.5 embryos, suspension-cultured 3 days

digestive/alimentary system
failure of palatal shelf elevation ( J:235669 )
• vertically oriented un-fused palatal shelves in maxillary explants from E13.5 embryos, suspension-cultured 3 days

growth/size/body
failure of palatal shelf elevation ( J:235669 )
• vertically oriented un-fused palatal shelves in maxillary explants from E13.5 embryos, suspension-cultured 3 days

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
cleft palate DOID:674 J:235669




Genotype
MGI:6152484
cx3
Allelic
Composition		 Golga5em3Lanyu/Golga5em3Lanyu
Golgb1em8Lanyu/Golgb1+
Genetic
Background		 FVB/NJ-Golga5em3Lanyu Golgb1em8Lanyu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Golga5em3Lanyu mutation (0 available); any Golga5 mutation (39 available)
Golgb1em8Lanyu mutation (0 available); any Golgb1 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:242905 )
N
• postnatal behavior

growth/size/body
growth/size/body region phenotype ( J:242905 )
N
• no obvious phenotype

mortality/aging
mortality/aging ( J:242905 )
N
• postnatal survival




Genotype
MGI:6152485
cx4
Allelic
Composition		 Golga5em3Lanyu/Golga5em3Lanyu
Golgb1em8Lanyu/Golgb1em8Lanyu
Genetic
Background		 FVB/NJ-Golga5em3Lanyu Golgb1em8Lanyu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Golga5em3Lanyu mutation (0 available); any Golga5 mutation (39 available)
Golgb1em8Lanyu mutation (0 available); any Golgb1 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal craniofacial morphology ( J:242905 )
• reduced alcian blue staining of cartilages in E14.5-E18.5 embryos
abnormal craniofacial bone morphology ( J:242905 )
• domed head in E14.5-E18.5 embryos
cleft palate ( J:242905 )
• in E14.5-E18.5 embryos
short snout ( J:242905 )
• in E14.5-E18.5 embryos

digestive/alimentary system
cleft palate ( J:242905 )
• in E14.5-E18.5 embryos

growth/size/body
cleft palate ( J:242905 )
• in E14.5-E18.5 embryos
short snout ( J:242905 )
• in E14.5-E18.5 embryos

skeleton
abnormal craniofacial bone morphology ( J:242905 )
• domed head in E14.5-E18.5 embryos




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory