Phenotypes associated with this allele

• Allele Symbol: Zfp106^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:6149962
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp106^tm1b(KOMP)Wtsi/Zfp106^tm1b(KOMP)Wtsi	involves: C57BL/6N	MGI:6150431
cx2	Tg(Mnx1-Zfp106,-EGFP)1Blk/0 Zfp106^tm1b(KOMP)Wtsi/Zfp106^tm1b(KOMP)Wtsi	involves: C57BL/6N	MGI:6150432
cx3	Tg(Mnx1-Zfp106,-EGFP)2Blk/0 Zfp106^tm1b(KOMP)Wtsi/Zfp106^tm1b(KOMP)Wtsi	involves: C57BL/6N	MGI:6150434

Genotype
MGI:6150431

hm1

• Allelic Composition: Zfp106^{tm1b(KOMP)Wtsi}/Zfp106^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0033_4_C03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle morphology ( J:241305 )

• in quadriceps muscles

• increased variation in fiber size

• very few centrally located nuclei

skeletal muscle fiber atrophy ( J:241305 )

• grouped atrophy in quadriceps muscles

• extensive, at 3 months of age

skeletal muscle fiber degeneration ( J:241305 )

• severe, at 3 months of age

behavior/neurological

abnormal physical strength ( J:241305 )

• reduced muscle strength from 4 weeks of age in all mice

decreased grip strength ( J:241305 )

nervous system

decreased motor neuron number ( J:241305 )

• significantly reduced number of choline-acetyltransferase-positive motor neurons in spinal cord

growth/size/body

cachexia ( J:241305 )

• due to muscle wasting

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis		DOID:332	OMIM:PS105400	J:241305

Genotype
MGI:6150432

cx2

• Allelic Composition: Tg(Mnx1-Zfp106,-EGFP)1Blk/0; Zfp106^{tm1b(KOMP)Wtsi}/Zfp106^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0033_4_C03

muscle

abnormal muscle fiber morphology ( J:241305 )

• significant suppression of muscle wasting compared to Zfp106 knockout allele alone

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:241305 )

• significant suppression of muscle wasting and of loss of grip strength compared to Zfp106 knockout allele alone

nervous system

abnormal motor neuron morphology ( J:241305 )

• significant restoration of number of choline-acetyltransferase-positive motor neurons in spinal cord compared to Zfp106 knockout allele alone

growth/size/body

abnormal body weight ( J:241305 )

• significant suppression of muscle wasting compared to Zfp106 knockout allele alone

Genotype
MGI:6150434

cx3

• Allelic Composition: Tg(Mnx1-Zfp106,-EGFP)2Blk/0; Zfp106^{tm1b(KOMP)Wtsi}/Zfp106^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0033_4_C03

muscle

abnormal muscle fiber morphology ( J:241305 )

• significant suppression of muscle wasting compared to Zfp106 knockout allele alone

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:241305 )

• significant suppression of muscle wasting and of loss of grip strength compared to Zfp106 knockout allele alone

nervous system

abnormal motor neuron morphology ( J:241305 )

• significant restoration of number of choline-acetyltransferase-positive motor neurons in spinal cord compared to Zfp106 knockout allele alone

growth/size/body

abnormal body weight ( J:241305 )

• significant suppression of muscle wasting compared to Zfp106 knockout allele alone