Phenotypes associated with this allele

• Allele Symbol: Zswim6^tm1.2Itl
• Allele Name: targeted mutation 1.2, inGenious Targeting Laboratory
• Allele ID: MGI:6149981
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zswim6^tm1.2Itl/Zswim6^tm1.2Itl	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * C57BL/6NTac	MGI:6157443

Genotype
MGI:6157443

hm1

• Allelic Composition: Zswim6^tm1.2Itl/Zswim6^tm1.2Itl
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:259070 )

• mice are born in normal Mendelian ratios but show a 40% mortality during the first few days after birth, followed by a very gradual decline through 4 weeks of age

growth/size/body

decreased body weight ( J:259070 )

• at P21, average body weight is about 80% of that in wild-type controls; however, this improves to 93% of controls by P100

nervous system

abnormal medium spiny neuron morphology ( J:259070 )

• adult mice show a 17% decrease in the number of nuclei labeling with CTIP2, a marker of medium spiny neurons, in the dorsal striatum; however, the density of medium spiny neurons is not changed

• the number of primary dendrites, dendritic branch points or nodes, dendritic tips, and total length are decreased in striatal medium spiny neurons; however, mean dendritic length is not changed

• Sholl analysis revealed reduced cumulative dendritic length and decreased Sholl intersections

• spine density is reduced by ~15%

• no major proliferation deficit or changes in apoptosis are observed

decreased striatum size ( J:259070 )

• a 15% decrease in striatal volume is noted at P21 and P80

• a non-significant 7% reduction in striatal volume is noted at P0

abnormal cerebral cortex morphology ( J:259070 )

• a 7% decrease of cortical volume is noted at P80

behavior/neurological

abnormal behavioral response to amphetamine ( J:259070 )

• mice show a significant increase in locomotor activity in response to a sub-threshold amphetamine challenge (2 mg/kg) that does not alter motility in wild-type controls

decreased anxiety-related response ( J:259070 )

• mice exhibit decreased thigmotaxis in the open-field test

abnormal grooming behavior ( J:259070 )

• mice spend a greater fraction of low mobility bouts grooming but do not show alterations in the power of these grooming events

• mice show a shift toward greater repetitions of phase 4 grooming relative to wild-type controls

impaired coordination ( J:259070 )

• in the accelerating rotarod test, mice exhibit impaired rotarod performance with significantly lower terminal speeds and shorter times to fail than wild-type controls

• however, force plate-mediated gait analysis showed no differences in average stride length, stride rate or velocity

hyperactivity ( J:259070 )

• mice exhibit modest hyperactivity in both IR-beam open-field tests and force plate actometry analysis, with increases in total distance traveled and a decrease in the number of low mobility bouts relative to wild-type controls

• in the open field test, mice show more beam breaks, more rearing events, and decreased thigmotaxis relative to wild-type controls

increased vertical activity ( J:259070 )

• in the open field test, mice show significantly more rearing events than wild-type controls

• force plate analysis revealed a significant increase in hind limb jumps relative to wild-type controls

increased locomotor activity ( J:259070 )

increased stereotypic behavior ( J:259070 )

• force plate analysis revealed a significant absolute directional bias in turning behaviors, measured over the course of a 60-minute session