Analysis Tools
immune system
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• papain-treated mice recruit normal numbers of eosinophils and express normal amounts of IL5 and IL13 from ILC2
• mice exhibit normal numbers of Peyer's patches and homeostasis and function of ILC2 and ILC3
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• mice exhibit a cell-intrinsic NK cell maturation block
• however, group 1 ILC lineage commitment occurs
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• increase in immature CD27+ NK cells
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• reduced innate lymphoid cell group 1 (ILC1) in the liver, lung and intraepithelial lymphocyte compartment of the gut
• however, ILC1 numbers in the small intestine lamina propria and salivary glands are normal and mice exhibit normal intestinal ILC2s, ILC3s, lung ILC2a and pother lymphoid and myeloid populations are normal
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• in the spleen, liver and lung
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• near complete loss of CD11b+ NK cells
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• cytokine-stimulated splenic and liver cells produce less IFNG than wild-type cells
• reduced proliferation and survival of mature NK cells
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• mice are impaired in their ability to clear RMA-S tumor cells compared with wild-type mice
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• from cytokine-stimulated splenic and liver cells
• from NK cell and ILC1 populations in the spleen and liver of mice infected with Listeria
• from NK cells of STm-infected mice
• however, liver ILC1 cells produce normal levels
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• mice infected with Listeria exhibit reduced bacterial loads in the spleen and liver with reduced IFNG from NK cells and ILC1 populations compared with wild-type mice
• however, Salmonella enterica serovar Typhimurium (STm)-infected mice exhibit normal infection of Peyer's patches, dissemination to the mesenteric lymph node or spleen, recruitment of myeloid cells, and ILC1 production of IFNG
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hematopoietic system
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• mice exhibit a cell-intrinsic NK cell maturation block
• however, group 1 ILC lineage commitment occurs
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• increase in immature CD27+ NK cells
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• reduced innate lymphoid cell group 1 (ILC1) in the liver, lung and intraepithelial lymphocyte compartment of the gut
• however, ILC1 numbers in the small intestine lamina propria and salivary glands are normal and mice exhibit normal intestinal ILC2s, ILC3s, lung ILC2a and pother lymphoid and myeloid populations are normal
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• in the spleen, liver and lung
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• near complete loss of CD11b+ NK cells
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• cytokine-stimulated splenic and liver cells produce less IFNG than wild-type cells
• reduced proliferation and survival of mature NK cells
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• mice are impaired in their ability to clear RMA-S tumor cells compared with wild-type mice
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