About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Del(7Chrna7-Fan1)3Arte
deletion, Chr 7, TaconicArtemis
MGI:6150456
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Del(7Chrna7-Fan1)3Arte/+ involves: C57BL/6J * C57BL/6NTac MGI:6150674


Genotype
MGI:6150674
ht1
Allelic
Composition
Del(7Chrna7-Fan1)3Arte/+
Genetic
Background
involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• slightly fewer than expected mice survive to weaning

behavior/neurological
N
• mice exhibit normal behavior including pain sensitivity, motor function, anxiety response, behaviors in the y-maze, alternation task and in cued and contextual fear conditioning
• PTZ-treated mice exhibit delayed onset and lower frequency of clonic and tonic seizures, but an increase in propensity for myoclonic jerks, compared with wild-type mice
• PTZ-treated mice exhibit more single spikes than wild-type mice and increased frequency and total duration of absence-like seizures in the frontal cortex
• mice exhibit protection from nicotine-clonic seizures compared with wild-type mice
• decreased distance spent in target quadrant of a Morris water maze
• when reintroduced into home cages
• however, mice do not exhibit an increase in restrain-induced corticosterone levels
• slightly during habituation
• however, activity following challenge with amphetamine or PCP is normal
• in the maximal electroshock seizure threshold assay, mice exhibit strong protection from electrically-induced tonic seizures compared with wild-type mice

nervous system
N
• mice exhibit normal brain weight and morphology with normal amphetamine- or PCP-disrupted prepulse inhibition
• PTZ-treated mice exhibit delayed onset and lower frequency of clonic and tonic seizures, but an increase in propensity for myoclonic jerks, compared with wild-type mice
• PTZ-treated mice exhibit more single spikes than wild-type mice and increased frequency and total duration of absence-like seizures in the frontal cortex
• mice exhibit protection from nicotine-clonic seizures compared with wild-type mice
• in the maximal electroshock seizure threshold assay, mice exhibit strong protection from electrically-induced tonic seizures compared with wild-type mice

growth/size/body
• beginning at 6 to 7 weeks of age as mice move into puberty

hearing/vestibular/ear
• reduced loudness dependence auditory evoked potential (LDAEP) in parietal and frontal cortex, but not the hippocampus
• reduced N1 and P2 AEP amplitudes in response to the first and second stimuli in the parietal cortex using the auditory double-click paradigm
• auditory stimulation (40 Hz) failed to induce an increase in gamma power in the parietal cortex, frontal cortex and hippocampus unlike in wild-type mice with a reduction in peak theta frequency in the hippocampus and prelimbic cortex
• however, mice exhibit normal AEP gating ratios and increase in gamma power in the prelimbic cortex

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chromosome 15q13.3 microdeletion syndrome DOID:0060394 OMIM:612001
J:260165





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory