Phenotypes associated with this allele

• Allele Symbol: Tg(Fabp4-Fam13a)1Iked
• Allele Name: transgene insertion 1, Koji Ikeda
• Allele ID: MGI:6150641
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Fabp4-Fam13a)1Iked/0	C57BL/6J-Tg(Fabp4-Fam13a)1Iked	MGI:6363546

Genotype
MGI:6363546

tg1

• Allelic Composition: Tg(Fabp4-Fam13a)1Iked/0
• Genetic Background: C57BL/6J-Tg(Fabp4-Fam13a)1Iked

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

adipose tissue phenotype ( J:258290 )

N • both sexes show normal body fat ratio and body fat distribution whether on a normal chow diet or a high-fat diet

N • on a normal chow diet, mice show normal expression of inflammatory cytokines in white adipose tissue (WAT)

N • on a high-fat diet, mice show normal expression of genes involved in brown adipose tissue (BAT) thermogenesis

increased white fat cell size ( J:258290 )

• after 14 weeks on a high-fat diet, white adipocyte size is modestly but significantly increased relative to wild-type controls

abnormal white adipose tissue physiology ( J:258290 )

• insulin-mediated Akt activation in WAT is significantly increased on a normal chow diet and after 12 weeks on a high-fat diet

• after 14 weeks on a high-fat diet, mRNA expression of inflammatory genes is modestly decreased in WAT relative to wild-type controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:258290 )

N • on a normal chow diet, mice show normal expression of adiponectin and leptin in WAT

N • on a high-fat diet, mice show no differences in body temperature, respiratory exchange ratio, energy expenditure or fatty acid oxidation in BAT relative to wild-type controls

decreased circulating free fatty acids level ( J:258290 )

• after 14 weeks on a high-fat diet, serum levels of free fatty acids (FFAs) are lower than those in wild-type controls

improved glucose tolerance ( J:258290 )

• on a normal chow diet, mice show better glucose tolerance than wild-type controls

• after 12 weeks on a high-fat diet, obesity-related glucose intolerance is improved relative to wild-type controls

increased insulin sensitivity ( J:258290 )

• on a normal chow diet, mice show higher insulin sensitivity than wild-type controls

• after 12 weeks on a high-fat diet, obesity-related insulin resistance is improved in association with preserved insulin signaling in WAT

impaired lipolysis ( J:258290 )

• after 14 weeks on a high-fat diet, serum levels of FFAs are decreased, white adipocyte size is increased, and expression of adipose triglyceride lipase (ATGL) in WAT is significantly lower than that in wild-type controls, suggesting reduced lipolysis in WAT

growth/size/body

growth/size/body region phenotype ( J:258290 )

N • both sexes show normal body weight gain whether on a normal chow diet or a high-fat diet

behavior/neurological

behavior/neurological phenotype ( J:258290 )

N • on a high-fat diet, mice show no differences in food intake or activity relative to wild-type controls