Phenotypes associated with this allele

• Allele Symbol: Arhgap29^tm1Murr
• Allele Name: targeted mutation 1, Stephen Murray
• Allele ID: MGI:6150826
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgap29^tm1Murr/Arhgap29^tm1Murr	C57BL/6NJ-Arhgap29^tm1Murr/GrsrJ	MGI:6150830
ht2	Arhgap29^tm1Murr/Arhgap29^+	C57BL/6NJ-Arhgap29^tm1Murr/GrsrJ	MGI:6150829
cx3	Arhgap29^tm1Murr/Arhgap29^+ Mafb^tm1.2Mardu/Mafb^+	involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA	MGI:7256936

Genotype
MGI:6150830

hm1

• Allelic Composition: Arhgap29^tm1Murr/Arhgap29^tm1Murr
• Genetic Background: C57BL/6NJ-Arhgap29^tm1Murr/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:257248 )

• no homozygotes found in heterozygous intercrosses assessed as early as E8.5

Genotype
MGI:6150829

ht2

• Allelic Composition: Arhgap29^tm1Murr/Arhgap29⁺
• Genetic Background: C57BL/6NJ-Arhgap29^tm1Murr/GrsrJ

craniofacial

failure of palatal shelf elevation ( J:257248 )

• at E14.5 palatal shelves are elevated in only 72% of heterozygotes compared with 100% of wild-type controls

palatal shelf fusion with tongue or mandible ( J:257248 )

abnormal oral epithelium morphology ( J:257248 )

• intraoral epithelial contacts, including palatal shelf to tongue adhesions and tooth bud adhesions, are found in 75% of heterozygotes at E13.5 and 52% of heterozygotes at E14.5, but none in wild-type sibling controls, and by E18.5 the palates of heterozygotes are well-formed indicating and allow complete palatogenesis

embryo

abnormal periderm morphology ( J:257248 )

• the sites of some oral epithelial adhesions have flat periderm nuclei and the periderm layer is reported to be occossionally discontinuous or disorganized

digestive/alimentary system

failure of palatal shelf elevation ( J:257248 )

• at E14.5 palatal shelves are elevated in only 72% of heterozygotes compared with 100% of wild-type controls

palatal shelf fusion with tongue or mandible ( J:257248 )

abnormal oral epithelium morphology ( J:257248 )

• intraoral epithelial contacts, including palatal shelf to tongue adhesions and tooth bud adhesions, are found in 75% of heterozygotes at E13.5 and 52% of heterozygotes at E14.5, but none in wild-type sibling controls, and by E18.5 the palates of heterozygotes are well-formed indicating and allow complete palatogenesis

growth/size/body

failure of palatal shelf elevation ( J:257248 )

• at E14.5 palatal shelves are elevated in only 72% of heterozygotes compared with 100% of wild-type controls

palatal shelf fusion with tongue or mandible ( J:257248 )

abnormal oral epithelium morphology ( J:257248 )

• intraoral epithelial contacts, including palatal shelf to tongue adhesions and tooth bud adhesions, are found in 75% of heterozygotes at E13.5 and 52% of heterozygotes at E14.5, but none in wild-type sibling controls, and by E18.5 the palates of heterozygotes are well-formed indicating and allow complete palatogenesis

Genotype
MGI:7256936

cx3

• Allelic Composition: Arhgap29^tm1Murr/Arhgap29⁺; Mafb^tm1.2Mardu/Mafb⁺
• Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA

embryo

embryo phenotype ( J:311539 )

N • mice born at normal Mendelian ratios

skeleton

skeleton phenotype ( J:311539 )

N • normal palatogenesis