Phenotypes associated with this allele

• Allele Symbol: Tmem237^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6150875
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem237^tm1b(EUCOMM)Hmgu/Tmem237^tm1b(EUCOMM)Hmgu	C57BL/6N-Tmem237^tm1b(EUCOMM)Hmgu/Ccpcz	MGI:6408726
ht2	Tmem237^tm1b(EUCOMM)Hmgu/Tmem237^+	C57BL/6N-Tmem237^tm1b(EUCOMM)Hmgu/Ccpcz	MGI:6408725

Genotype
MGI:6408726

hm1

• Allelic Composition: Tmem237^{tm1b(EUCOMM)Hmgu}/Tmem237^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Tmem237^{tm1b(EUCOMM)Hmgu}/Ccpcz
• Cell Lines: HEPD0752_3_B12

Data Sources

IMPC Data for Tmem237

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - CCP-IMG

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - CCP-IMG

preweaning lethality, complete penetrance ( J:211773 )

IMPC - CCP-IMG

Genotype
MGI:6408725

ht2

• Allelic Composition: Tmem237^{tm1b(EUCOMM)Hmgu}/Tmem237⁺
• Genetic Background: C57BL/6N-Tmem237^{tm1b(EUCOMM)Hmgu}/Ccpcz
• Cell Lines: HEPD0752_3_B12

Data Sources

IMPC Data for Tmem237

behavior/neurological

increased freezing behavior ( J:211773 )

♂

IMPC - CCP-IMG

cardiovascular system

abnormal heart morphology ( J:211773 )

IMPC - CCP-IMG

enlarged heart ( J:211773 )

IMPC - CCP-IMG

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:211773 )

♂

IMPC - CCP-IMG

small adrenal glands ( J:211773 )

♂

IMPC - CCP-IMG

abnormal mammary gland morphology ( J:211773 )

♂

IMPC - CCP-IMG

abnormal testis morphology ( J:211773 )

♂

IMPC - CCP-IMG

small testis ( J:211773 )

♂

IMPC - CCP-IMG

growth/size/body

enlarged heart ( J:211773 )

IMPC - CCP-IMG

homeostasis/metabolism

increased circulating triglyceride level ( J:211773 )

IMPC - CCP-IMG

increased circulating calcium level ( J:211773 )

♀

IMPC - CCP-IMG

increased circulating potassium level ( J:211773 )

♀

IMPC - CCP-IMG

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - CCP-IMG

increased circulating aspartate transaminase level ( J:211773 )

IMPC - CCP-IMG

increased circulating chloride level ( J:211773 )

♀

IMPC - CCP-IMG

immune system

abnormal lymph node morphology ( J:211773 )

♀

IMPC - CCP-IMG

enlarged lymph nodes ( J:211773 )

♀

IMPC - CCP-IMG

integument

abnormal mammary gland morphology ( J:211773 )

♂

IMPC - CCP-IMG

limbs/digits/tail

long tibia ( J:211773 )

IMPC - CCP-IMG

nervous system

abnormal brain morphology ( J:211773 )

IMPC - CCP-IMG

increased brain size ( J:211773 )

♀

IMPC - CCP-IMG

reproductive system

abnormal testis morphology ( J:211773 )

♂

IMPC - CCP-IMG

small testis ( J:211773 )

♂

IMPC - CCP-IMG

skeleton

long tibia ( J:211773 )

IMPC - CCP-IMG

vision/eye

abnormal retina morphology ( J:211773 )

IMPC - CCP-IMG