Phenotypes associated with this allele

• Allele Symbol: Mgme1^tm1.2Lrsn
• Allele Name: targeted mutation 1.2, Nils-Goran Larsson
• Allele ID: MGI:6150912
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mgme1^tm1.2Lrsn/Mgme1^tm1.2Lrsn	involves: C57BL/6NTac	MGI:6151397

Genotype
MGI:6151397

hm1

• Allelic Composition: Mgme1^tm1.2Lrsn/Mgme1^tm1.2Lrsn
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:259702 )

N • mice exhibit normal fertility and testes morphology

hematopoietic system

anemia ( J:259702 )

• mild than in other mitochondria DNA mutator mice

• moderate at 70 weeks without reticulocytosis

decreased hemoglobin content ( J:259702 )

• mild at 70 weeks

cellular

decreased mitochondrial DNA content ( J:259702 )

• depletion and deletion

abnormal mitochondrial physiology ( J:259702 )

• abnormal mitochondrial transcription

• however, mitochondrial protein levels are normal

growth/size/body

growth/size/body region phenotype ( J:259702 )

N • mice exhibit normal aging