Phenotypes associated with this allele

• Allele Symbol: Lrit1^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6151090
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrit1^tm1b(EUCOMM)Hmgu/Lrit1^tm1b(EUCOMM)Hmgu	involves: C57BL/6N * FVB/N	MGI:6151091

Genotype
MGI:6151091

hm1

• Allelic Composition: Lrit1^{tm1b(EUCOMM)Hmgu}/Lrit1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:260354 )

N • mice exhibit normal overall retina morphology, viability and laminar organization up to 3 months

abnormal cone electrophysiology ( J:260354 )

• reduced b-wave amplitudes with increasing background light intensity

• cone ON or OFF bipolar cells exhibit 10-fold more sensitive dark-adapted responses compared with wild-type mice

behavior/neurological

abnormal optokinetic reflex ( J:260354 )

• reduced visual acuity under conditions requiring temporally challenging discrimination in a steady light background

• however, discrimination at any speed is normal