Phenotypes associated with this allele

• Allele Symbol: Ddc^tm1Umon
• Allele Name: targeted mutation 1, Umrao Monani
• Allele ID: MGI:6151137
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddc^tm1Umon/Ddc^tm1Umon	B6.129S(FVB)-Ddc^tm1Umon	MGI:6188070
hm2	Ddc^tm1Umon/Ddc^tm1Umon	FVB.129S(B6)-Ddc^tm1Umon	MGI:6188072
hm3	Ddc^tm1Umon/Ddc^tm1Umon	involves: 129S/SvEv * C57BL/6 * FVB/N	MGI:6188064

Genotype
MGI:6188070

hm1

• Allelic Composition: Ddc^tm1Umon/Ddc^tm1Umon
• Genetic Background: B6.129S(FVB)-Ddc^tm1Umon

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:250494 )

• no homozygotes are produced from a heterozygote x heterozygote mating

Genotype
MGI:6188072

hm2

• Allelic Composition: Ddc^tm1Umon/Ddc^tm1Umon
• Genetic Background: FVB.129S(B6)-Ddc^tm1Umon

mortality/aging

embryonic lethality, complete penetrance ( J:250494 )

• no homozygotes are produced from a heterozygote x heterozygote mating

Genotype
MGI:6188064

hm3

• Allelic Composition: Ddc^tm1Umon/Ddc^tm1Umon
• Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

behavior/neurological

impaired coordination ( J:250494 )

• decreased latency to fall on rotarod is detected between 11 and 12 weeks of age

abnormal maternal nurturing ( J:250494 )

♀ • homozygous females exhibit poor maternal care

embryo

abnormal embryo development ( J:250494 )

• some E15.5 embryos appear poorly developed

decreased embryo size ( J:250494 )

• some E15.5 embryos appear shriveled

abnormal embryonic tissue morphology ( J:250494 )

• some E15.5 embryos appear grossly dysmorphic

growth/size/body

decreased embryo size ( J:250494 )

• some E15.5 embryos appear shriveled

homeostasis/metabolism

impaired adaptive thermogenesis ( J:250494 )

• mice are sensitive to cold exposure, exhibiting lower body temperatures than controls and a longer recovery period

decreased dopamine level ( J:250494 )

• 25% reduction in dopamine levels in the striatum

• however, dopaminergic cells are not altered in number or morphology

decreased serotonin level ( J:250494 )

• 60% reduction in serotonin levels

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:250494 )

• fewer homozygotes (8%) are produced than expected from a heterozygote x heterozygote mating

reproductive system

reduced female fertility ( J:250494 )

♀