All Phenotypes Cnot3<tm1.1Kjkb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cnot3^tm1.1Kjkb
targeted mutation 1.1, Keiji Kuba
MGI:6151142

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atg5^tm1Myok/Atg5^tm1Myok Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb Tg(Ckmm-cre)5Khn/0	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB	MGI:6151158
cn2	Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb Tg(Ckmm-cre)5Khn/0	involves: 129P2/OlaHsd * C57BL/6 * FVB	MGI:6151150
cn3	Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:6151153
cn4	Atg7^tm1Tchi/Atg7^tm1Tchi Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb Tg(Ckmm-cre)5Khn/0	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB	MGI:6151152
cn5	Atg7^tm1Tchi/Atg7^tm1Tchi Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N	MGI:6151155
cn6	Atg7^tm1Tchi/Atg7^tm1Tchi Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf^{Tg(Myh6-cre/Esr1)1Jmk}	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N	MGI:6151156

Allelic Composition	Atg5^tm1Myok/Atg5^tm1Myok Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg5^tm1Myok mutation (3 available); any Atg5 mutation (29 available)
Cnot3^tm1.1Kjkb mutation (0 available); any Cnot3 mutation (35 available)
Tg(Ckmm-cre)5Khn mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal autophagosome formation ( J:260012 )

• impaired autophagosome formation

mortality/aging

premature death ( J:260012 )

cardiovascular system

increased heart weight ( J:260012 )

decreased cardiac muscle contractility ( J:260012 )

prolonged QT interval ( J:260012 )

cellular

abnormal autophagosome formation ( J:260012 )

• impaired autophagosome formation

muscle

decreased cardiac muscle contractility ( J:260012 )

growth/size/body

increased heart weight ( J:260012 )

Allelic Composition	Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnot3^tm1.1Kjkb mutation (0 available); any Cnot3 mutation (35 available)
Tg(Ckmm-cre)5Khn mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:260012 )

• all mice die between 3 weeks of age and P30

cardiovascular system

decreased myocardial fiber number ( J:260012 )

cardiac muscle necrosis ( J:260012 )

• focal with reduced cytoplasmic contents and vacuole formation

enlarged heart ( J:260012 )

increased heart weight ( J:260012 )

decreased cardiac muscle contractility ( J:260012 )

irregular heartbeat ( J:260012 )

prolonged QT interval ( J:260012 )

cardiomyopathy ( J:260012 )

muscle

muscle phenotype ( J:260012 )

N	• muscles appear normal

decreased myocardial fiber number ( J:260012 )

cardiac muscle necrosis ( J:260012 )

• focal with reduced cytoplasmic contents and vacuole formation

decreased cardiac muscle contractility ( J:260012 )

cardiomyopathy ( J:260012 )

growth/size/body

enlarged heart ( J:260012 )

increased heart weight ( J:260012 )

Allelic Composition	Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mutation (5 available); any A1cf mutation (39 available)
Cnot3^tm1.1Kjkb mutation (0 available); any Cnot3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:260012 )

• mice treated with tamoxifen at 3 months develop lethal heart failure

cardiovascular system

congestive heart failure ( J:260012 )

• mice treated with tamoxifen at 3 months develop lethal heart failure

Allelic Composition	Atg7^tm1Tchi/Atg7^tm1Tchi Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7^tm1Tchi mutation (3 available); any Atg7 mutation (51 available)
Cnot3^tm1.1Kjkb mutation (0 available); any Cnot3 mutation (35 available)
Tg(Ckmm-cre)5Khn mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal autophagosome formation ( J:260012 )

• impaired autophagosome formation

mortality/aging

premature death ( J:260012 )

• mice survive to 7 weeks after birth

cardiovascular system

cardiovascular system phenotype ( J:260012 )

N	• mice exhibit normal heart weight, cardiac contractility and QT interval

cellular

abnormal autophagosome formation ( J:260012 )

• impaired autophagosome formation

Allelic Composition	Atg7^tm1Tchi/Atg7^tm1Tchi Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mutation (5 available); any A1cf mutation (39 available)
Atg7^tm1Tchi mutation (3 available); any Atg7 mutation (51 available)
Cnot3^tm1.1Kjkb mutation (0 available); any Cnot3 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:260012 )

• tamoxifen-treated mice survive until P40

cardiovascular system

decreased cardiac muscle contractility ( J:260012 )

• not as severe as in mice Cnot3^tm2.1Tya A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mice

muscle

decreased cardiac muscle contractility ( J:260012 )

• not as severe as in mice Cnot3^tm2.1Tya A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mice

Allelic Composition	Atg7^tm1Tchi/Atg7^tm1Tchi Cnot3^tm1.1Kjkb/Cnot3^tm1.1Kjkb A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf^{Tg(Myh6-cre/Esr1)1Jmk}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased cardiac muscle contractility ( J:260012 )

• as in mice with one copy of A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}

muscle

decreased cardiac muscle contractility ( J:260012 )

• as in mice with one copy of A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}

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