Analysis Tools
behavior/neurological
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• when fed a choice diet with ad libitum access to high-fat 12.6% sucrose (HFS) diet, low-fat 17% sucrose (17S) diet, and low-fat no-sucrose (NS) diet for 8 weeks, mice show a lower intake of sucrose in the form of the 17S diet, and a higher intake of the low-fat NS diet
• however, no differences in total energy intake are observed in mice fed the choice diet or a high-fat no-sucrose (HFNS) diet relative to diet-matched wild-type controls
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growth/size/body
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• when mice are fed a choice diet with ad libitum access to high-fat 12.6% sucrose (HFS) diet, low-fat 17% sucrose (17S) diet, and low-fat no-sucrose (NS) diet for 8 weeks, mean weekly weight gain is significantly lower than that in wild-type mice fed the choice diet
• however, no differences in weight gain are observed on a high-fat no-sucrose (HFNS) diet
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homeostasis/metabolism
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• in response to a 120-min sucrose-tolerance test, mice exhibit significantly lower plasma glucose levels than those in wild-type controls at 15 and 30 min after a sucrose gavage, indicating reduced sucrose uptake
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• when gavaged with 3 g/kg sucrose after a 12-hour fast, mice exhibit mean plasma acetate levels that are several times higher than those in wild-type controls at 4 and 6 hours post-gavage
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• mice with ad libitum access to a choice diet of high-fat 12.6% sucrose (HFS), low-fat 17% sucrose (17S), and low-fat no-sucrose (NS) show a trend towards reduced liver triglyceride levels; however, this reduction (-20%) is nonsignificant
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adipose tissue
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• when mice are fed a choice diet with ad libitum access to high-fat 12.6% sucrose (HFS) diet, low-fat 17% sucrose (17S) diet, and low-fat no-sucrose (NS) diet for 8 weeks, body fat percentage is significantly lower than that in wild-type mice fed the choice diet
• however, lean mass gain is normal on the choice diet and no differences in body fat percentage or lean mass gain are noted in mice fed a high-fat no-sucrose (HFNS) diet relative to diet-matched wild-type controls
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liver/biliary system
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• mice with ad libitum access to a choice diet of high-fat 12.6% sucrose (HFS), low-fat 17% sucrose (17S), and low-fat no-sucrose (NS) show a trend towards reduced liver triglyceride levels; however, this reduction (-20%) is nonsignificant
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