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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cherpem1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:6151421
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cherpem1(IMPC)J/Cherpem1(IMPC)J C57BL/6NJ-Cherpem1(IMPC)J/Mmjax MGI:6492763
ht2
 		Cherpem1(IMPC)J/Cherp+ C57BL/6NJ-Cherpem1(IMPC)J/Mmjax MGI:6731278


Genotype
MGI:6492763
hm1
Allelic
Composition		 Cherpem1(IMPC)J/Cherpem1(IMPC)J
Genetic
Background		 C57BL/6NJ-Cherpem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cherpem1(IMPC)J mutation (2 available); any Cherp mutation (34 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Cherpem1(IMPC)J/Cherpem1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos show abnormal morula morphology. Blastocysts grown in vitro hatch from the zona pellucida but outgrowths show no defined inner call mass and few trophectoderm cells.

embryo
abnormal inner cell mass morphology ( J:279207 )
• in vitro outgrowth assays show no defined inner cell mass (ICM) after 3 days in culture
abnormal trophectoderm morphology ( J:279207 )
• in vitro, few trophectoderm (TE) cells are observed after 3 days in culture
abnormal morula morphology ( J:279207 )
• some embryos recovered at E3.5 appear as irregular morulae

mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )
• homozygous embryos are recovered at expected Mendelian ratios at E3.5 but appear as irregular morulae or early blastocysts; no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system
abnormal embryo implantation ( J:279207 )
• in vitro, blastocysts hatch from the zona pellucida but form outgrowths with no defined ICM and few trophectoderm cells after 3 days in culture




Genotype
MGI:6731278
ht2
Allelic
Composition		 Cherpem1(IMPC)J/Cherp+
Genetic
Background		 C57BL/6NJ-Cherpem1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cherpem1(IMPC)J mutation (2 available); any Cherp mutation (34 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory