Phenotypes associated with this allele

• Allele Symbol: Sp9^tm1.1Zyan
• Allele Name: targeted mutation 1.1, Zhengang Yang
• Allele ID: MGI:6152404
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sp9^tm1.1Zyan/Sp9^tm1.1Zyan	involves: 129S6/SvEvTac * C57BL/6J	MGI:6161736
cx2	Bax^tm1Sjk/Bax^tm1Sjk Sp9^tm1.1Zyan/Sp9^tm1.1Zyan	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J	MGI:6161737

Genotype
MGI:6161736

hm1

• Allelic Composition: Sp9^tm1.1Zyan/Sp9^tm1.1Zyan
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

weakness ( J:238868 )

• mutant mice failed to thrive and developed general weakness from P7 onward

cellular

increased neuron apoptosis ( J:238868 )

• mutant null mice lose immature striatopallidal medium-sized spiny neurons due to increased Bax-dependent apoptosis

decreased neuronal precursor proliferation ( J:238868 )

• mutant null mice lose striatopallidal medium-sized spiny neurons due to decreased proliferation of striatopallidal medium-sized spiny neuron progenitors

mortality/aging

postnatal lethality, complete penetrance ( J:238868 )

• mutant mice started to die at P14, and none survived beyond P22

nervous system

increased neuron apoptosis ( J:238868 )

• mutant null mice lose immature striatopallidal medium-sized spiny neurons due to increased Bax-dependent apoptosis

decreased neuronal precursor proliferation ( J:238868 )

• mutant null mice lose striatopallidal medium-sized spiny neurons due to decreased proliferation of striatopallidal medium-sized spiny neuron progenitors

decreased brain weight ( J:238868 )

• brain size and weight of mutant mice are grossly reduced compared to controls at P20

abnormal striatum morphology ( J:238868 )

• atrophy of the striatum

abnormal medium spiny neuron morphology ( J:238868 )

• mutant null mice lose striatopallidal medium-sized spiny neurons due to decreased proliferation of striatopallidal medium-sized spiny neuron progenitors

decreased striatum size ( J:238868 )

• the volume of mutant striatum is reduced to 54% of controls at P9

Genotype
MGI:6161737

cx2

• Allelic Composition: Bax^tm1Sjk/Bax^tm1Sjk; Sp9^tm1.1Zyan/Sp9^tm1.1Zyan
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

nervous system

nervous system phenotype ( J:238868 )

N • striatal cell death seen in single mutant SP9 KO mice is nearly absent in the Sp9;Bax/ double mutants at P3

decreased striatum size ( J:238868 )

• at P15, mutant striatum is larger in double mutants than single SP9 KO mice, but smaller than wild-type controls