Phenotypes associated with this allele

• Allele Symbol: Ccdc186^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6152423
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccdc186^em1(IMPC)Mbp/Ccdc186^em1(IMPC)Mbp	C57BL/6NCrl-Ccdc186^em1(IMPC)Mbp/MbpMmucd	MGI:7471921
hm2	Ccdc186^em1(IMPC)Mbp/Ccdc186^em1(IMPC)Mbp	C57BL/6NCrl-Ccdc186^em1(IMPC)Mbp/Mmucd	MGI:6288376
ht3	Ccdc186^em1(IMPC)Mbp/Ccdc186^+	C57BL/6NCrl-Ccdc186^em1(IMPC)Mbp/MbpMmucd	MGI:7471920
ht4	Ccdc186^em1(IMPC)Mbp/Ccdc186^+	C57BL/6NCrl-Ccdc186^em1(IMPC)Mbp/Mmucd	MGI:6461128

Genotype
MGI:7471921

hm1

• Allelic Composition: Ccdc186^em1(IMPC)Mbp/Ccdc186^em1(IMPC)Mbp
• Genetic Background: C57BL/6NCrl-Ccdc186^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Ccdc186

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial morphology ( J:211773 )

♀

IMPC - UCD

embryo

embryonic growth retardation ( J:211773 )

♀

IMPC - UCD

abnormal placenta morphology ( J:211773 )

IMPC - UCD

growth/size/body

embryonic growth retardation ( J:211773 )

♀

IMPC - UCD

homeostasis/metabolism

edema ( J:211773 )

♀

IMPC - UCD

vision/eye

microphthalmia ( J:211773 )

IMPC - UCD

Genotype
MGI:6288376

hm2

• Allelic Composition: Ccdc186^em1(IMPC)Mbp/Ccdc186^em1(IMPC)Mbp
• Genetic Background: C57BL/6NCrl-Ccdc186^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Ccdc186

cardiovascular system

abnormal blood vessel morphology ( J:211773 )

IMPC - UCD

abnormal placenta vasculature ( J:211773 )

♀

IMPC - UCD

hemorrhage ( J:211773 )

IMPC - UCD

embryo

abnormal placenta morphology ( J:211773 )

♀

IMPC - UCD

abnormal placenta vasculature ( J:211773 )

♀

IMPC - UCD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:7471920

ht3

• Allelic Composition: Ccdc186^em1(IMPC)Mbp/Ccdc186⁺
• Genetic Background: C57BL/6NCrl-Ccdc186^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Ccdc186

embryo

abnormal placenta morphology ( J:211773 )

IMPC - UCD

vision/eye

microphthalmia ( J:211773 )

IMPC - UCD

Genotype
MGI:6461128

ht4

• Allelic Composition: Ccdc186^em1(IMPC)Mbp/Ccdc186⁺
• Genetic Background: C57BL/6NCrl-Ccdc186^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Ccdc186

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - UCD

no spontaneous movement ( J:211773 )

IMPC - UCD

cardiovascular system

abnormal blood vessel morphology ( J:211773 )

IMPC - UCD

hemorrhage ( J:211773 )

IMPC - UCD

vision/eye

abnormal eye morphology ( J:211773 )

♀

IMPC - UCD