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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ipo7em1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:6152503
Summary 3 genotypes


Genotype
MGI:7715132
hm1
Allelic
Composition		 Ipo7em1(IMPC)Mbp/Ipo7em1(IMPC)Mbp
Genetic
Background		 C57BL/6NCrl-Ipo7em1(IMPC)Mbp/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ipo7em1(IMPC)Mbp mutation (1 available); any Ipo7 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ipo7em1(IMPC)Mbp/Ipo7em1(IMPC)Mbp mice exhibit embryonic lethality. No embryos are recovered at E7.5 and abnormal blastocysts are recovered at E3.5. Blastocysts grown in vitro hatch from the zona pellucida and form outgrowths.

mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )
• no homozygous embryos or excess resorption sites are observed at E7.5; however, abnormal looking blastocysts are recovered at expected Mendelian ratios at E3.5

embryo
abnormal blastocyst morphology ( J:279207 )
• embryos recovered at E3.5 appear as abnormal blastocysts
• however, blastocysts do hatch from the zona pellucida and form outgrowths after 3 days in culture




Genotype
MGI:6262707
hm2
Allelic
Composition		 Ipo7em1(IMPC)Mbp/Ipo7em1(IMPC)Mbp
Genetic
Background		 C57BL/6N-Ipo7em1(IMPC)Mbp/Ucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ipo7em1(IMPC)Mbp mutation (1 available); any Ipo7 mutation (82 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6288528
ht3
Allelic
Composition		 Ipo7em1(IMPC)Mbp/Ipo7+
Genetic
Background		 C57BL/6N-Ipo7em1(IMPC)Mbp/Ucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ipo7em1(IMPC)Mbp mutation (1 available); any Ipo7 mutation (82 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

growth/size/body
enlarged spleen ( J:211773 )
IMPC - UCD

hematopoietic system
enlarged spleen ( J:211773 )
IMPC - UCD

homeostasis/metabolism

immune system
enlarged spleen ( J:211773 )
IMPC - UCD

integument

renal/urinary system

respiratory system

vision/eye
anophthalmia ( J:211773 )
IMPC - UCD




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory