Phenotypes associated with this allele

• Allele Symbol: Sfmbt2^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6152634
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sfmbt2^em1(IMPC)Mbp/Sfmbt2^em1(IMPC)Mbp	C57BL/6NCrl-Sfmbt2^em1(IMPC)Mbp/Mmucd	MGI:6288720
ht2	Sfmbt2^em1(IMPC)Mbp/Sfmbt2^+	C57BL/6NCrl-Sfmbt2^em1(IMPC)Mbp/Mmucd	MGI:6493091

Genotype
MGI:6288720

hm1

• Allelic Composition: Sfmbt2^em1(IMPC)Mbp/Sfmbt2^em1(IMPC)Mbp
• Genetic Background: C57BL/6NCrl-Sfmbt2^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Sfmbt2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:211773 )

IMPC - UCD

craniofacial

abnormal pharyngeal arch morphology ( J:211773 )

IMPC - UCD

embryo

abnormal pharyngeal arch morphology ( J:211773 )

IMPC - UCD

abnormal embryo turning ( J:211773 )

♀

IMPC - UCD

abnormal neural tube morphology ( J:211773 )

IMPC - UCD

abnormal neural tube closure ( J:211773 )

♀

IMPC - UCD

mortality/aging

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - UCD

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

nervous system

abnormal neural tube morphology ( J:211773 )

IMPC - UCD

abnormal neural tube closure ( J:211773 )

♀

IMPC - UCD

abnormal hindbrain development ( J:211773 )

♀

IMPC - UCD

Genotype
MGI:6493091

ht2

• Allelic Composition: Sfmbt2^em1(IMPC)Mbp/Sfmbt2⁺
• Genetic Background: C57BL/6NCrl-Sfmbt2^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Sfmbt2

behavior/neurological

increased freezing behavior ( J:211773 )

♂

IMPC - UCD

cardiovascular system

abnormal heart morphology ( J:211773 )

IMPC - UCD

embryo

embryonic growth retardation ( J:211773 )

IMPC - UCD

abnormal neural tube morphology ( J:211773 )

IMPC - UCD

abnormal placenta morphology ( J:211773 )

IMPC - UCD

abnormal placenta size ( J:211773 )

IMPC - UCD

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - UCD

enlarged kidney ( J:211773 )

♂

IMPC - UCD

homeostasis/metabolism

edema ( J:211773 )

IMPC - UCD

immune system

abnormal lymph node morphology ( J:211773 )

♀

IMPC - UCD

enlarged lymph nodes ( J:211773 )

♀

IMPC - UCD

liver/biliary system

abnormal liver morphology ( J:211773 )

♀

IMPC - UCD

nervous system

abnormal neural tube morphology ( J:211773 )

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

♂

IMPC - UCD

enlarged kidney ( J:211773 )

♂

IMPC - UCD

vision/eye

microphthalmia ( J:211773 )

IMPC - UCD