Phenotypes associated with this allele

• Allele Symbol: Shpk^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6152640
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shpk^em1(IMPC)Mbp/Shpk^em1(IMPC)Mbp	C57BL/6NCrl-Shpk^em1(IMPC)Mbp/Mmucd	MGI:6370434

Genotype
MGI:6370434

hm1

• Allelic Composition: Shpk^em1(IMPC)Mbp/Shpk^em1(IMPC)Mbp
• Genetic Background: C57BL/6NCrl-Shpk^em1(IMPC)Mbp/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal urine homeostasis ( J:351905 )

• increase in urinary sedoheptulose and erythritol levels

abnormal metabolism ( J:351905 )

• pentose phosphate pathway (PPP) metabolomics are disrupted in the liver and urine, with a reduction in PPP metabolites sedoheptulose-7-phosphate (S7P), glyceraldehyde-3-phosphate, erythrose-4-phosphate (E4P), ribose-5-phosphate, and 6-phosphogluconate in the liver and a decrease of hexose sugars (glucose and fructose) and AMP, indicating PPP dysregulation in the liver

renal/urinary system

renal/urinary system phenotype ( J:351905 )

N • mice show no obvious differences in the kidneys

abnormal urine homeostasis ( J:351905 )

• increase in urinary sedoheptulose and erythritol levels

liver/biliary system

liver/biliary system phenotype ( J:351905 )

N • mice show no obvious differences in the liver