Analysis Tools
reproductive system
 |
• in mature caudal epididymal spermatozoa
• occasional extra doublet microtubules located outside fibrous sheath
• normal midpiece morphology
|
|
|
• disorganized fibrous sheath in mature caudal epididymal spermatozoa with unwound fibers and increased cytosolic space between axoneme and plasma membrane
• occasional extra doublet microtubules located outside fibrous sheath
|
|
|
• in mature caudal epididymal spermatozoa
• disorganized axonemal structure of proximal and distal regions of principal piece with more or fewer doublet microtubules than normal
|
|
|
• fibrous sheath transverse ribs preferentially disrupted or expanded and of abnormal morphology
• disorganized fibrous sheath with unwound fibers and increased cytosolic space between axoneme and plasma membrane
• abnormal morphology of fibrous sheath adjacent to doublet microtubules 3 and 8
• abnormal morphology of ribs in medial section of longitudinally lying flagella
• significantly higher frequency of vertically aligned ribs in lateral sections of longitudinally lying flagella
• normal morphology of longitudinal columns in medial section of longitudinally lying flagella
|
|
|
• significantly lower occurrence of hyperactivation after 2 h incubation
|
|
|
• only one pup born from 17 homozygous mutant male to wild-type female matings during 3 months
• inability of sperm to fertilize oocytes (cumulus-intact or cumulus-free) in vitro
• inability of sperm to penetrate zona pellucida of oocytes in vitro
• normal sperm fusion with oocytes free of zona pellucida in vitro
• normal binding of sperm to zona pellucida of oocytes in vitro
• normal acrosome reaction of sperm cells in vitro
|
|
|
• significantly lower average path velocity (VAP), straight line velocity (VSL) and curvilinear velocity (VCL) at both 10 min and 120 min of incubation
|
|
|
• decreased percentage motile cells in capacitating or non-capacitating medium
|
|
|
• in capacitating or non-capacitating medium
|
|
|
• only one pup born from 17 homozygous mutant male to wild-type female matings during 3 months
|
cellular
|
|
• in mature caudal epididymal spermatozoa
• occasional extra doublet microtubules located outside fibrous sheath
• normal midpiece morphology
|
|
|
• disorganized fibrous sheath in mature caudal epididymal spermatozoa with unwound fibers and increased cytosolic space between axoneme and plasma membrane
• occasional extra doublet microtubules located outside fibrous sheath
|
|
|
• in mature caudal epididymal spermatozoa
• disorganized axonemal structure of proximal and distal regions of principal piece with more or fewer doublet microtubules than normal
|
|
|
• fibrous sheath transverse ribs preferentially disrupted or expanded and of abnormal morphology
• disorganized fibrous sheath with unwound fibers and increased cytosolic space between axoneme and plasma membrane
• abnormal morphology of fibrous sheath adjacent to doublet microtubules 3 and 8
• abnormal morphology of ribs in medial section of longitudinally lying flagella
• significantly higher frequency of vertically aligned ribs in lateral sections of longitudinally lying flagella
• normal morphology of longitudinal columns in medial section of longitudinally lying flagella
|
|
|
• significantly lower average path velocity (VAP), straight line velocity (VSL) and curvilinear velocity (VCL) at both 10 min and 120 min of incubation
|
|
|
• decreased percentage motile cells in capacitating or non-capacitating medium
|
|
|
• in capacitating or non-capacitating medium
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| male infertility | DOID:12336 | J:247126 | ||
