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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nf1tm2.1Kest
targeted mutation 2.1, Robert A Kesterson
MGI:6153137
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nf1tm2.1Kest/Nf1tm2.1Kest involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NTac MGI:6275133
ht2
 		Nf1tm1d(KOMP)Wtsi/Nf1tm2.1Kest involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/N MGI:6275188


Genotype
MGI:6275133
hm1
Allelic
Composition		 Nf1tm2.1Kest/Nf1tm2.1Kest
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm2.1Kest mutation (0 available); any Nf1 mutation (161 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:234172 )
• mice are viable and indistinguishable from heterozygotes, do not develop tumors in the spinal columns or peripheral nerves, and do not show disruption of myelinated or non-myelinated axons




Genotype
MGI:6275188
ht2
Allelic
Composition		 Nf1tm1d(KOMP)Wtsi/Nf1tm2.1Kest
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/N
Cell Lines EPD0033_1_F12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1d(KOMP)Wtsi mutation (0 available); any Nf1 mutation (161 available)
Nf1tm2.1Kest mutation (0 available); any Nf1 mutation (161 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:234172 )
• mice are viable and display no overt phenotype, with no tumor development up to 24 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory