Phenotypes associated with this allele

• Allele Symbol: Prdm15^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6153140
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Prdm15^tm1c(EUCOMM)Wtsi/Prdm15^tm1c(EUCOMM)Wtsi Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: C57BL/6J * C57BL/6N	MGI:6403992
cn2	Prdm15^tm1c(EUCOMM)Wtsi/Prdm15^tm1c(EUCOMM)Wtsi Tg(Nes-cre)1Kln/0	involves: C57BL/6J * C57BL/6N	MGI:6404011

Genotype
MGI:6403992

cn1

• Allelic Composition: Prdm15^{tm1c(EUCOMM)Wtsi}/Prdm15^{tm1c(EUCOMM)Wtsi}; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0114_3_G01

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:285408 )

• embryos die in utero starting at E12.5; only 16.7% of embryos are obtained at E12.5 with no live embryos recovered at P0

growth/size/body

decreased embryo size ( J:285408 )

embryo

decreased embryo size ( J:285408 )

nervous system

abnormal brain morphology ( J:285408 )

• at E12.5, embryos exhibit a spectrum of brain malformations affecting primarily the anteriormost structures similar to those observed in Prdm15^{tm1a(EUCOMM)Wtsi} homozygotes

Genotype
MGI:6404011

cn2

• Allelic Composition: Prdm15^{tm1c(EUCOMM)Wtsi}/Prdm15^{tm1c(EUCOMM)Wtsi}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0114_3_G01

normal phenotype

no abnormal phenotype detected ( J:285408 )

• embryos exhibit no apparent brain defects at E12.5, and mice are born at the expected Mendelian ratios and develop into healthy adults