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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ncf2tm1b(EUCOMM)Wtsi
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:6153187
Summary 3 genotypes


Genotype
MGI:6188106
hm1
Allelic
Composition		 Ncf2tm1b(EUCOMM)Wtsi/Ncf2tm1b(EUCOMM)Wtsi
Genetic
Background		 B6(Cg)-Ncf2tm1b(EUCOMM)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncf2tm1b(EUCOMM)Wtsi mutation (1 available); any Ncf2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system
lung inflammation ( J:260777 )
• increased susceptibility of A fumigatus-induced pneumonia
increased susceptibility to fungal infection ( J:260777 )
• following challenge with spores from A fumigatus, mice develop multiple foci of inflammatory cells containing germinated hyphae, in contrast, controls exhibit little response and no germinated hyphae

respiratory system
lung inflammation ( J:260777 )
• increased susceptibility of A fumigatus-induced pneumonia




Genotype
MGI:6188109
hm2
Allelic
Composition		 Ncf2tm1b(EUCOMM)Wtsi/Ncf2tm1b(EUCOMM)Wtsi
Genetic
Background		 NZM2328.B6(Cg)-Ncf2tm1b(EUCOMM)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncf2tm1b(EUCOMM)Wtsi mutation (1 available); any Ncf2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal redox activity ( J:260777 )
• NADPH oxidase activity in macrophages, dendritic cells and neutrophils is absent

hematopoietic system
increased activated T cell number ( J:260777 )
• increased numbers of activated memory T cells
abnormal spleen germinal center morphology ( J:260777 )
• spontaneous germinal center formation

homeostasis/metabolism
increased urine protein level ( J:260777 )
• proteinuria phenotype is more severe than in heterozygote or NZM2328 mice

immune system
increased activated T cell number ( J:260777 )
• increased numbers of activated memory T cells
abnormal spleen germinal center morphology ( J:260777 )
• spontaneous germinal center formation

mortality/aging
premature death ( J:260777 )
• mice do not survive beyond 6 months

renal/urinary system
increased urine protein level ( J:260777 )
• proteinuria phenotype is more severe than in heterozygote or NZM2328 mice
abnormal renal glomerulus morphology ( J:260777 )
• kidney disease is observed by 4 months of age
• glomerular hypercellularity
abnormal mesangial matrix morphology ( J:260777 )
• mesangial matrix deposition
renal glomerular protein deposits ( J:260777 )
• glomerular deposition of IgG and C3
renal glomerular immunoglobulin deposits ( J:260777 )
• glomerular deposition of IgG
abnormal kidney interstitium morphology ( J:260777 )
• interstitial inflammation




Genotype
MGI:6188110
ht3
Allelic
Composition		 Ncf2tm1b(EUCOMM)Wtsi/Ncf2+
Genetic
Background		 NZM2328.B6(Cg)-Ncf2tm1b(EUCOMM)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncf2tm1b(EUCOMM)Wtsi mutation (1 available); any Ncf2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal redox activity ( J:260777 )
• NADPH oxidase activity is reduced but not absent

hematopoietic system
increased CD4-positive, alpha-beta memory T cell number ( J:260777 )
• increased numbers of activated memory T cells
increased activated T cell number ( J:260777 )
• increased numbers of activated memory T cells
abnormal spleen germinal center morphology ( J:260777 )
• spontaneous germinal center formation

homeostasis/metabolism
increased urine protein level ( J:260777 )
• proteinuria
• phenotype is more severe than in NZM2328 mice

immune system
increased CD4-positive, alpha-beta memory T cell number ( J:260777 )
• increased numbers of activated memory T cells
increased activated T cell number ( J:260777 )
• increased numbers of activated memory T cells
abnormal spleen germinal center morphology ( J:260777 )
• spontaneous germinal center formation

mortality/aging
premature death ( J:260777 )
• mice do not survive beyond 10 months

renal/urinary system
increased urine protein level ( J:260777 )
• proteinuria
• phenotype is more severe than in NZM2328 mice
abnormal renal glomerulus morphology ( J:260777 )
• kidney disease is observed by 4 months of age, but is not as severe as in homozygote




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory