Phenotypes associated with this allele

• Allele Symbol: Med23^{em1(IMPC)Wtsi}
• Allele Name: endonuclease-mediated mutation 1, Wellcome Trust Sanger Institute
• Allele ID: MGI:6153490
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Med23^em1(IMPC)Wtsi/Med23^em1(IMPC)Wtsi	C57BL/6N-Med23^em1(IMPC)Wtsi/Wtsi	MGI:6262865
ht2	Med23^em1(IMPC)Wtsi/Med23^+	C57BL/6N-Med23^em1(IMPC)Wtsi/Wtsi	MGI:6696818

Genotype
MGI:6262865

hm1

• Allelic Composition: Med23^{em1(IMPC)Wtsi}/Med23^{em1(IMPC)Wtsi}
• Genetic Background: C57BL/6N-Med23^{em1(IMPC)Wtsi}/Wtsi

Data Sources

IMPC Data for Med23

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal chorion morphology ( J:261316 )

• unpatterned chorion at E9.5

abnormal placenta morphology ( J:261316 )

• branching morphology defect at E9.5

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment at E9.5

• biased differentiation (diploid/polyploid trophoblast)

abnormal trophoblast giant cell morphology ( J:261316 )

• abnormal trophoblast giant cell size and morphology at E9.5

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

lethality throughout fetal growth and development, complete penetrance ( J:261316 )

• complete lethality at E14.5

Genotype
MGI:6696818

ht2

• Allelic Composition: Med23^{em1(IMPC)Wtsi}/Med23⁺
• Genetic Background: C57BL/6N-Med23^{em1(IMPC)Wtsi}/Wtsi

Data Sources

IMPC Data for Med23

growth/size/body

increased lean body mass ( J:211773 )

♂

IMPC - WTSI

hematopoietic system

increased red blood cell distribution width ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

decreased circulating fructosamine level ( J:211773 )

IMPC - WTSI

increased circulating HDL cholesterol level ( J:211773 )

♀

IMPC - WTSI

skeleton

decreased bone mineral content ( J:211773 )

♀

IMPC - WTSI