Analysis Tools
nervous system
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• positioning of the callosal projection neurons, especially those expressing Plxnd2, in the superficial layer of the cortex is disturbed, with wider distribution of and increased callosal projection neuron migration to the deep layer region
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• localization of excitatory cortical neurons in the occipital cortex is disorganized at postnatal week 3, with cells distributed more widely in the vertical direction of the cortex
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• mean length of spines on the apical dendrites of the layer II pyramidal neurons (superficial pyramidal neurons) in the piriform cortex is shorter than in controls
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• intracortical excitation propagation is abnormal; the degree of excitation in the upper cortical layers of the visual cortex is lower, in particular there is a reduction in the lateral propagation in layers II/III 8.4 ms after the stimulation
• the reduction in the horizontal propagation of excitation in layers II/III persists even when GABAergic transmission is inhibited by treatment with the GABA(A)-receptor blocker bicuculline
• treatment with blebbistatin to block myosin 2b activity has no effect on excitation propagation in layers II/III of the visual cortex compared to wild-type mice which show a reduction in excitation propagation with treatment
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• neurons in the piriform cortex are less responsive to NMDA
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