Analysis Tools
homeostasis/metabolism
|
• adults develop progressive proteinuria with massive albuminuria at 40 months of age
|
albuminuria
(
J:234732
)
|
• massive albuminuria is seen at 40 months of age, about 60-fold higher than in controls
• however, serum albumin is not different
|
renal/urinary system
|
• adults develop progressive proteinuria with massive albuminuria at 40 months of age
|
albuminuria
(
J:234732
)
|
• massive albuminuria is seen at 40 months of age, about 60-fold higher than in controls
• however, serum albumin is not different
|
|
• adults show collapsed F-actin in podocytes
• cell junctions of effaced foot processes resemble tight junctions
|
|
• adults show widespread foot process effacement
|
|
• newborns exhibit persistence of cuboidal podocytes, wide foot processes and tight-junction-like cell junctions in lieu of slit-diaphragms
• slit-diaphragms are decreased in adults
|
|
• adults show microvillar transformation
|
|
• adults exhibit focal segmental glomerulosclerosis, with the presence of protein casts and tubulointerstitial nephropathy
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| nephrotic syndrome | DOID:1184 | J:234732 | ||
