Phenotypes associated with this allele

• Allele Symbol: Mtcl1^tm1.1Atsuz
• Allele Name: targeted mutation 1.1, Atsushi Suzuki
• Allele ID: MGI:6154024
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mtcl1^tm1.1Atsuz/Mtcl1^tm1.1Atsuz	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6JJcl	MGI:6154043

Genotype
MGI:6154043

cn1

• Allelic Composition: Mtcl1^tm1.1Atsuz/Mtcl1^tm1.1Atsuz
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6JJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

Purkinje cell degeneration ( J:253309 )

abnormal Purkinje cell axon morphology ( J:253309 )

• reduced length of Ank3-positive region in Purkinje cell axons at age 3 weeks

abnormal Purkinje cell dendrite morphology ( J:253309 )

• dilation of distal dendrites at age 2 months

abnormal axon initial segment morphology ( J:253309 )

• irregular AIS morphology in Purkinje cells at age 2 months

axonal spheroids ( J:253309 )

• Purkinje cell axonal swellings at age 2 months

behavior/neurological

abnormal motor coordination/balance ( J:253309 )

• starting at age 3-4 weeks