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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox10tm8.1Weg
targeted mutation 8.1, Michael Wegner
MGI:6154154
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox10tm8.1Weg/Sox10tm8.1Weg involves: 129P2/OlaHsd * C3H MGI:6154159
ht2
 		Sox10tm8.1Weg/Sox10+ involves: 129P2/OlaHsd * C3H MGI:6154203


Genotype
MGI:6154159
hm1
Allelic
Composition		 Sox10tm8.1Weg/Sox10tm8.1Weg
Genetic
Background		 involves: 129P2/OlaHsd * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm8.1Weg mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:260791 )
• mice die immediately after birth

nervous system
abnormal nervous system morphology ( J:260791 )
• peripheral nerves are thinner in CNS-proximal regions and sometimes appear defasciculated in more distal regions
decreased Schwann cell number ( J:260791 )
• Schwann cells are reduced in numbers in spinal nerves at E18.5
abnormal Schwann cell physiology ( J:260791 )
• marker analysis indicates that the remaining Schwann cells are severely delayed in their capacity to differentiate or are incapable of differentiation
abnormal oligodendrocyte physiology ( J:260791 )
• the number of Mbp and Plp-1 expressing oligodendrocytes are reduced at E18.5, indicating a delay in oligodendroglial differentiation
• however, oligodendroglial cells in the spinal cord appear normal at E18.5




Genotype
MGI:6154203
ht2
Allelic
Composition		 Sox10tm8.1Weg/Sox10+
Genetic
Background		 involves: 129P2/OlaHsd * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm8.1Weg mutation (0 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
megacolon ( J:260791 )
• fewer than 5% of mice succumb to a megacolon around time of weaning

integument
belly spot ( J:260791 )
• fully penetrant white belly spot from second generation backcross to C3H and onwards

nervous system
abnormal oligodendrocyte physiology ( J:260791 )
• the number of Mbp and Plp-1 expressing oligodendrocytes are reduced in the spinal cord at P3 but not later times, indicating a slight and transient delay in oligodendroglial differentiation during the first postnatal days
• however, sciatic nerves, development and maintenance of Schwann cells and PNS myelin, and spinal cord development appear normal

pigmentation
belly spot ( J:260791 )
• fully penetrant white belly spot from second generation backcross to C3H and onwards




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory