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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hmcesem1Dfel
endonuclease-mediated mutation 1, Douglas E Feldman
MGI:6154268
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hmcesem1Dfel/Hmcesem1Dfel involves: 129 * C57BL/6N MGI:6155019
ht2
Hmcesem1Dfel/Hmces+ involves: 129 * C57BL/6N MGI:6155020


Genotype
MGI:6155019
hm1
Allelic
Composition
Hmcesem1Dfel/Hmcesem1Dfel
Genetic
Background
involves: 129 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmcesem1Dfel mutation (0 available); any Hmces mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• altered gene expression in 224 loci due to changes in frequency of 5-methylcytosine (5mC) and its oxidized derivatives 5hmC, 5fC and 5caC in embryonic stem cells
• altered gene expression due to differentially methylated regions (hyper- and hypomethylated relative to wild-type) in E9.5 embryos
• increase in 5-methylcytosine (5mC) and Tet-oxidized 5mC derivatives 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxycytosine (5caC) levels in embryonic stem cells
• increase in 5mC and 5hmC levels in E9.5 embryos
• increased fraction of highly methylated CpG-enriched regions in E9.5 embryos
• 1589 differentially methylated regions (hyper- and hypomethylated relative to wild-type) in E9.5 embryos

growth/size/body
• underweight at age 3 weeks

mortality/aging
• significantly fewer embryos found than expected Mendelian ratio at E9.5-E16.5
• significantly fewer pups born than expected Mendelian ratio
• significantly fewer embryos found than expected Mendelian ratio at E9.5-E16.5 but no empty implantation sites or absorbed conceptuses in utero
• significantly fewer pups born than expected Mendelian ratio

reproductive system
• from in-cross of homozygous mutants




Genotype
MGI:6155020
ht2
Allelic
Composition
Hmcesem1Dfel/Hmces+
Genetic
Background
involves: 129 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmcesem1Dfel mutation (0 available); any Hmces mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some embryos failed to develop properly and were found as a mass of highly vascularized, undifferentiated tissue





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory