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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Psmb10Tub6
Tub6
MGI:6154286
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Psmb10Tub6/Psmb10Tub6 B6.C3Fe-Psmb10Tub6 MGI:6154973
hm2
 		Psmb10Tub6/Psmb10Tub6 C3HeB/FeJ-Psmb10Tub6 MGI:6154971
hm3
 		Psmb10Tub6/Psmb10Tub6 C.C3Fe-Psmb10Tub6 MGI:6154975
ht4
 		Psmb10Tub6/Psmb10+ C3HeB/FeJ-Psmb10Tub6 MGI:6154970
ht5
 		Psmb10tm1Mgro/Psmb10Tub6 involves: 129S2/SvPas * C3HeB/FeJ MGI:6154976


Genotype
MGI:6154973
hm1
Allelic
Composition		 Psmb10Tub6/Psmb10Tub6
Genetic
Background		 B6.C3Fe-Psmb10Tub6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb10Tub6 mutation (1 available); any Psmb10 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Genotype
MGI:6154971
hm2
Allelic
Composition		 Psmb10Tub6/Psmb10Tub6
Genetic
Background		 C3HeB/FeJ-Psmb10Tub6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb10Tub6 mutation (1 available); any Psmb10 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:261081 )
• moribund by 6 to 12 weeks

immune system
increased granulocyte number ( J:261081 )
• develops later in a commensal-independent manner
• proportion and total numbers in peripheral blood
decreased B cell number ( J:261081 )
• develops later in a commensal-independent manner
increased circulating tumor necrosis factor level ( J:261081 )
• alpha, beta and gamma levels in some mice
increased inflammatory response ( J:261081 )
• systemic inflammation and severe combined immunodeficiency that is independent of microbiome
skin inflammation ( J:261081 )
• progressive skin disorder with increased neutrophil granulocytes

integument
skin inflammation ( J:261081 )
• progressive skin disorder with increased neutrophil granulocytes

adipose tissue

growth/size/body
decreased body size ( J:261081 )

endocrine/exocrine glands

hematopoietic system
increased granulocyte number ( J:261081 )
• develops later in a commensal-independent manner
• proportion and total numbers in peripheral blood
decreased B cell number ( J:261081 )
• develops later in a commensal-independent manner

homeostasis/metabolism
increased circulating tumor necrosis factor level ( J:261081 )
• alpha, beta and gamma levels in some mice




Genotype
MGI:6154975
hm3
Allelic
Composition		 Psmb10Tub6/Psmb10Tub6
Genetic
Background		 C.C3Fe-Psmb10Tub6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb10Tub6 mutation (1 available); any Psmb10 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Genotype
MGI:6154970
ht4
Allelic
Composition		 Psmb10Tub6/Psmb10+
Genetic
Background		 C3HeB/FeJ-Psmb10Tub6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb10Tub6 mutation (1 available); any Psmb10 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:261081 )
• 5 to 7 days after a sublethal dose infection with Listeria monocytogenes with a failure to eliminate the pathogen, reduced pathogen-specific T cell responses and IFNG production

immune system
abnormal T cell activation ( J:261081 )
• Listeria monocytogenes-infected mice exhibit reduced pathogen-specific T cell responses compared with wild-type mice
decreased interferon-gamma secretion ( J:261081 )
• from CD8+ T cells of Listeria monocytogenes-infected mice
• however, production in response to phorbol 12-myristate 13-acetate and ionomycin is normal
increased susceptibility to bacterial infection induced morbidity/mortality ( J:261081 )
• 5 to 7 days after a sublethal dose infection with Listeria monocytogenes with a failure to eliminate the pathogen, reduced pathogen-specific T cell responses and IFNG production

hematopoietic system
abnormal T cell activation ( J:261081 )
• Listeria monocytogenes-infected mice exhibit reduced pathogen-specific T cell responses compared with wild-type mice




Genotype
MGI:6154976
ht5
Allelic
Composition		 Psmb10tm1Mgro/Psmb10Tub6
Genetic
Background		 involves: 129S2/SvPas * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psmb10tm1Mgro mutation (1 available); any Psmb10 mutation (18 available)
Psmb10Tub6 mutation (1 available); any Psmb10 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system

hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory