About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Oas2M1Apb
mutation 1, Australian Phenomics Facility
MGI:6154625
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Oas2M1Apb/Oas2M1Apb involves: C57BL/6J * CBA/CaJ MGI:6154712
ht2
 		Oas2M1Apb/Oas2+ involves: C57BL/6J * CBA/CaJ MGI:6154713


Genotype
MGI:6154712
hm1
Allelic
Composition		 Oas2M1Apb/Oas2M1Apb
Genetic
Background		 involves: C57BL/6J * CBA/CaJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oas2M1Apb mutation (0 available); any Oas2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:248944 )
N
• at 2 days post-partum
• development of mammary ductal network during puberty
• development of lobulo-alveolar units during pregnancy
• onset of milk protein synthesis during pregnancy
abnormal mammary gland growth during lactation ( J:248944 )
• failure of alveolar expansion
abnormal mammary gland alveolus morphology ( J:248944 )
• failure of alveolar expansion during lactation
abnormal mammary gland physiology ( J:248944 )
• reduced expression of all major milk components at 2 days post-partum
• retention of lipid droplets and colostrum
decreased mammary gland epithelial cell proliferation ( J:248944 )
• as indicated by decreased BrdU incorporation
lactation failure ( J:248944 )
• at 2 days post-partum

integument
abnormal mammary gland growth during lactation ( J:248944 )
• failure of alveolar expansion
abnormal mammary gland alveolus morphology ( J:248944 )
• failure of alveolar expansion during lactation
abnormal mammary gland physiology ( J:248944 )
• retention of lipid droplets and colostrum
• reduced expression of all major milk components at 2 days post-partum
decreased mammary gland epithelial cell proliferation ( J:248944 )
• as indicated by decreased BrdU incorporation
lactation failure ( J:248944 )
• at 2 days post-partum

cellular
increased apoptosis ( J:248944 )
• of mammary gland epithelial cells as indicated by increased number of cleaved caspase 3-postive cells
decreased mammary gland epithelial cell proliferation ( J:248944 )
• as indicated by decreased BrdU incorporation




Genotype
MGI:6154713
ht2
Allelic
Composition		 Oas2M1Apb/Oas2+
Genetic
Background		 involves: C57BL/6J * CBA/CaJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oas2M1Apb mutation (0 available); any Oas2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands

integument




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory