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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Oas2M1Apb
mutation 1, Australian Phenomics Facility
MGI:6154625
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Oas2M1Apb/Oas2M1Apb involves: C57BL/6J * CBA/CaJ MGI:6154712
ht2
 		Oas2M1Apb/Oas2+ involves: C57BL/6J * CBA/CaJ MGI:6154713


Genotype
MGI:6154712
hm1
Allelic
Composition		 Oas2M1Apb/Oas2M1Apb
Genetic
Background		 involves: C57BL/6J * CBA/CaJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oas2M1Apb mutation (0 available); any Oas2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:248944 )
N
• at 2 days post-partum
• development of mammary ductal network during puberty
• development of lobulo-alveolar units during pregnancy
• onset of milk protein synthesis during pregnancy
abnormal mammary gland growth during lactation ( J:248944 )
• failure of alveolar expansion
abnormal mammary gland alveolus morphology ( J:248944 )
• failure of alveolar expansion during lactation
abnormal mammary gland physiology ( J:248944 )
• retention of lipid droplets and colostrum
• reduced expression of all major milk components at 2 days post-partum
decreased mammary gland epithelial cell proliferation ( J:248944 )
• as indicated by decreased BrdU incorporation
lactation failure ( J:248944 )
• at 2 days post-partum

integument
abnormal mammary gland growth during lactation ( J:248944 )
• failure of alveolar expansion
abnormal mammary gland alveolus morphology ( J:248944 )
• failure of alveolar expansion during lactation
abnormal mammary gland physiology ( J:248944 )
• retention of lipid droplets and colostrum
• reduced expression of all major milk components at 2 days post-partum
decreased mammary gland epithelial cell proliferation ( J:248944 )
• as indicated by decreased BrdU incorporation
lactation failure ( J:248944 )
• at 2 days post-partum

cellular
increased apoptosis ( J:248944 )
• of mammary gland epithelial cells as indicated by increased number of cleaved caspase 3-postive cells
decreased mammary gland epithelial cell proliferation ( J:248944 )
• as indicated by decreased BrdU incorporation




Genotype
MGI:6154713
ht2
Allelic
Composition		 Oas2M1Apb/Oas2+
Genetic
Background		 involves: C57BL/6J * CBA/CaJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oas2M1Apb mutation (0 available); any Oas2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands

integument




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory