Phenotypes associated with this allele

• Allele Symbol: Lhfpl4^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:6154882
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lhfpl4^tm1Lex/Lhfpl4^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:6155607

Genotype
MGI:6155607

hm1

• Allelic Composition: Lhfpl4^tm1Lex/Lhfpl4^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal postsynaptic density morphology ( J:254795 )

• decrease in Gabra2 and Gphn cluster area in hippocampal CA1 region

• decrease in Gabrg2 and Gphn cluster area in cultured dissociated hippocampal neurons

abnormal miniature inhibitory postsynaptic currents ( J:254795 )

• synaptic charge reduced by ~60% in cultured dissociated hippocampal neurons

• loss of mIPSCs in CA1 pyramidal neurons in acute hippocampal slices

• mIPSC-mediated charge transfer reduced by ~80% in CA1 pyramidal neurons in acute hippocampal slices

• normal rise and decay of fast mIPSCs in CA1 pyramidal neurons in acute hippocampal slices

• normal amplitude of slow mIPSCs in CA1 pyramidal neurons in acute hippocampal slices

decreased miniature inhibitory postsynaptic current amplitude ( J:254795 )

• reduced frequency and amplitude of fast mIPSCs in CA1 pyramidal neurons in acute hippocampal slices

decreased miniature inhibitory postsynaptic current frequency ( J:254795 )

• reduced frequency and amplitude of fast mIPSCs in CA1 pyramidal neurons in acute hippocampal slices

increased miniature inhibitory postsynaptic current frequency ( J:254795 )

• increased frequency of slow mIPSCs in CA1 pyramidal neurons in acute hippocampal slices

behavior/neurological

behavior/neurological phenotype ( J:254795 )

N • no obvious anomalies

N • inhibitory presynaptic domain in hippocampus

N • miniature excitatory postsynaptic currents (mEPSCs) in CA1 pyramidal neurons in acute hippocampal slices

N • charge transfer in non-pyramidal cells in CA1 stratum oriens, radiatum, or lacunosum-moleculare

mortality/aging

mortality/aging ( J:254795 )

N • viable, survive to adulthood

reproductive system

reproductive system phenotype ( J:254795 )

N • fertile