Phenotypes associated with this allele

• Allele Symbol: Eif4a3^tm1.1Dlsi
• Allele Name: targeted mutation 1.1, Debra L Silver
• Allele ID: MGI:6155638
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Eif4a3^tm1.1Dlsi/Eif4a3^+ Emx1^tm1(cre)Krj/Emx1^+	involves: 129S2/SvPas * C57BL/6J	MGI:6382122

Genotype
MGI:6382122

cn1

• Allelic Composition: Eif4a3^tm1.1Dlsi/Eif4a3⁺; Emx1^tm1(cre)Krj/Emx1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

microcephaly ( J:235650 )

• mice exhibit severe microcephaly, with an average 70% reduction in cortical area of whole mount brains at P12

nervous system

abnormal telencephalon development ( J:235650 )

• the dorsal telencephalon is largely absent at E14.5 and of the remaining dorsal telencephalon tissue, the cortex is extremely thinned and neurons are disorganized

decreased brain size ( J:235650 )

• smaller brain at E12.5

decreased forebrain size ( J:235650 )

• forebrain is smaller at E12.5

abnormal neocortex morphology ( J:235650 )

• extensive apoptosis is seen in neocortices at E11.5 and is present in both neurons and neural stem cells throughout the dorsal cortex

• mitotic index is increased in neocortices at E11.5

• Pax6+ neural stem cells are reduced in density in neocortices at E12.5 and the thickness of the TUJ1+ neuronal layer is increased

decreased neocortex size ( J:235650 )

• neocortices are smaller at E12.5 and are 30% thinner

absent telencephalon ( J:235650 )

• the dorsal telencephalon is largely absent at E14.5

abnormal neuronal stem cell morphology ( J:235650 )

• Pax6+ neural stem cells are reduced in density in neocortices at E12.5, indicating neural stem cell depletion