Phenotypes associated with this allele

• Allele Symbol: Scn4b^tm1.2Geh
• Allele Name: targeted mutation 1.2, Gregg E Homanics
• Allele ID: MGI:6155711
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn4b^tm1.2Geh/Scn4b^tm1.2Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6161342

Genotype
MGI:6161342

hm1

• Allelic Composition: Scn4b^tm1.2Geh/Scn4b^tm1.2Geh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to amphetamine ( J:261348 )

♂ • amphetamine-induced locomotor activity was significantly reduced in male mutant mice compared to wild-type controls

♂ • while the locomotor activity rose during the first few minutes following the injection, it peaked quickly and declined much faster than controls

nervous system

abnormal action potential ( J:261348 )

• a reduced ability of back-propagating action potentials to evoke dendritic calcium transients in core accumbens medium spiny neurons

decreased single cell response threshold ( J:261348 )

• alterations of gene expression significantly shifted action potentials (APs) threshold in core accumbens medium spiny neurons; APs are noticeably more depolarized compared to controls

reduced long-term depression ( J:261348 )

• a large reduction of the probability of core accumbens medium spiny neurons to induce spike-timing-dependent long-term depression (tLTD), but not spike-timing-dependent long-term potentiation (tLTP), in mutant mice