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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnmt3crahu
rahu
MGI:6156101
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnmt3crahu/Dnmt3crahu involves: C57BL/6J * FVB/NJ MGI:6156318
ht2
 		Dnmt3cem1Sky/Dnmt3crahu involves: C57BL/6J * CBA * FVB/NJ MGI:6156319
ht3
 		Dnmt3cem4Sky/Dnmt3crahu involves: C57BL/6J * CBA * FVB/NJ MGI:6156320
ht4
 		Dnmt3cem5Sky/Dnmt3crahu involves: C57BL/6J * CBA * FVB/NJ MGI:6156325


Genotype
MGI:6156318
hm1
Allelic
Composition		 Dnmt3crahu/Dnmt3crahu
Genetic
Background		 involves: C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3crahu mutation (0 available); any Dnmt3c mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:244795 )
N
• female mice exhibit normal meiosis, embryonic development, or adult somatic functions
arrest of male meiosis ( J:244795 )
• during mid-pachynema, possibly at stage IV, with meiotic double strand break defects
increased male germ cell apoptosis ( J:244795 )
• during mid-pachynema, possibly at stage IV
abnormal DNA methylation during gametogenesis ( J:244795 )
• reduced methylation and repression of transposons and retrotransposons in the male germline

cellular
arrest of male meiosis ( J:244795 )
• during mid-pachynema, possibly at stage IV, with meiotic double strand break defects
increased male germ cell apoptosis ( J:244795 )
• during mid-pachynema, possibly at stage IV
abnormal DNA methylation during gametogenesis ( J:244795 )
• reduced methylation and repression of transposons and retrotransposons in the male germline

endocrine/exocrine glands




Genotype
MGI:6156319
ht2
Allelic
Composition		 Dnmt3cem1Sky/Dnmt3crahu
Genetic
Background		 involves: C57BL/6J * CBA * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3cem1Sky mutation (0 available); any Dnmt3c mutation (13 available)
Dnmt3crahu mutation (0 available); any Dnmt3c mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:244795 )
N
• female mice exhibit normal reproduction

endocrine/exocrine glands




Genotype
MGI:6156320
ht3
Allelic
Composition		 Dnmt3cem4Sky/Dnmt3crahu
Genetic
Background		 involves: C57BL/6J * CBA * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3cem4Sky mutation (0 available); any Dnmt3c mutation (13 available)
Dnmt3crahu mutation (0 available); any Dnmt3c mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular

endocrine/exocrine glands

reproductive system




Genotype
MGI:6156325
ht4
Allelic
Composition		 Dnmt3cem5Sky/Dnmt3crahu
Genetic
Background		 involves: C57BL/6J * CBA * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3cem5Sky mutation (0 available); any Dnmt3c mutation (13 available)
Dnmt3crahu mutation (0 available); any Dnmt3c mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:244795 )
N
• male mice exhibit normal testes weight and post-meiotic germ cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory