Phenotypes associated with this allele

• Allele Symbol: Nmnat1^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6156360
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nmnat1^tm1c(EUCOMM)Wtsi/Nmnat1^tm1c(EUCOMM)Wtsi Tg(Crx-cre/ERT2)1Tfur/0	involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N	MGI:6272876
cn2	Nmnat1^tm1c(EUCOMM)Wtsi/Nmnat1^tm1c(EUCOMM)Wtsi Tg(Chx10-EGFP/cre,-ALPP)2Clc/0	involves: C57BL/6J * C57BL/6N * SJL	MGI:6272875
cn3	Nmnat1^tm1c(EUCOMM)Wtsi/Nmnat1^tm1c(EUCOMM)Wtsi Tg(Rho-icre)1Ck/0	involves: C57BL/6J * C57BL/6N * SJL	MGI:6272877

Genotype
MGI:6272876

cn1

• Allelic Composition: Nmnat1^{tm1c(EUCOMM)Wtsi}/Nmnat1^{tm1c(EUCOMM)Wtsi}; Tg(Crx-cre/ERT2)1Tfur/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

short photoreceptor outer segment ( J:267630 )

retina photoreceptor degeneration ( J:267630 )

• by P28, most photoreceptor cells are degenerated and the outer nuclear layer is absent in the retina

vision/eye

abnormal retina morphology ( J:267630 )

• retinal lamination defects are seen at P6

short photoreceptor outer segment ( J:267630 )

retina photoreceptor degeneration ( J:267630 )

• by P28, most photoreceptor cells are degenerated and the outer nuclear layer is absent in the retina

retina outer nuclear layer degeneration ( J:267630 )

• progressive thinning of the outer nuclear layer

decreased total retina thickness ( J:267630 )

• reduction in overall retinal thickness is apparent by P15

Genotype
MGI:6272875

cn2

• Allelic Composition: Nmnat1^{tm1c(EUCOMM)Wtsi}/Nmnat1^{tm1c(EUCOMM)Wtsi}; Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * SJL

vision/eye

thin retina inner nuclear layer ( J:267630 )

• mice exhibit reduced thickness of the inner nuclear layer at P9

thin retina outer nuclear layer ( J:267630 )

• mice exhibit reduced thickness of the outer nuclear layer at P9

decreased total retina thickness ( J:267630 )

• mice exhibit a reduction of retinal thickness by P15

retina degeneration ( J:267630 )

• mice exhibit early onset of retinal degeneration by P9-P15

Genotype
MGI:6272877

cn3

• Allelic Composition: Nmnat1^{tm1c(EUCOMM)Wtsi}/Nmnat1^{tm1c(EUCOMM)Wtsi}; Tg(Rho-icre)1Ck/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * SJL

nervous system

abnormal retina rod cell outer segment morphology ( J:267630 )

• no rod outer segments are detectable by P15

retina rod cell degeneration ( J:267630 )

• the outer nuclear layer is reduced at P28 but not P7, indicating that most rods are lost

vision/eye

abnormal retina rod cell outer segment morphology ( J:267630 )

• no rod outer segments are detectable by P15

retina rod cell degeneration ( J:267630 )

• the outer nuclear layer is reduced at P28 but not P7, indicating that most rods are lost

retina outer nuclear layer degeneration ( J:267630 )

• the outer nuclear layer is reduced at P28 but not P7, indicating that most rods are lost

retina degeneration ( J:267630 )