Phenotypes associated with this allele

• Allele Symbol: Atp8b1^em1(IMPC)Tcp
• Allele Name: endonuclease-mediated mutation 1, The Centre for Phenogenomics
• Allele ID: MGI:6156424
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp8b1^em1(IMPC)Tcp/Atp8b1^em1(IMPC)Tcp	C57BL/6NCrl-Atp8b1^em1(IMPC)Tcp/Tcp	MGI:6261934

Genotype
MGI:6261934

hm1

• Allelic Composition: Atp8b1^em1(IMPC)Tcp/Atp8b1^em1(IMPC)Tcp
• Genetic Background: C57BL/6NCrl-Atp8b1^em1(IMPC)Tcp/Tcp

Data Sources

IMPC Data for Atp8b1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - TCP

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - TCP

abnormal startle reflex ( J:211773 )

IMPC - TCP

decreased startle reflex ( J:211773 )

♂

IMPC - TCP

decreased grip strength ( J:211773 )

IMPC - TCP

increased grip strength ( J:211773 )

♂

IMPC - TCP

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

IMPC - TCP

abnormal retina blood vessel morphology ( J:211773 )

IMPC - TCP

decreased heart weight ( J:211773 )

♂

IMPC - TCP

decreased heart rate ( J:211773 )

♂

IMPC - TCP

prolonged RR interval ( J:211773 )

♂

IMPC - TCP

endocrine/exocrine glands

small seminal vesicle ( J:211773 )

♂

IMPC - TCP

abnormal pancreas morphology ( J:211773 )

IMPC - TCP

growth/size/body

increased lean body mass ( J:211773 )

IMPC - TCP

polycystic kidney ( J:211773 )

IMPC - TCP

enlarged kidney ( J:211773 )

♂

IMPC - TCP

enlarged urinary bladder ( J:211773 )

♂

IMPC - TCP

enlarged spleen ( J:211773 )

♀

IMPC - TCP

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - TCP

hematopoietic system

enlarged spleen ( J:211773 )

♀

IMPC - TCP

decreased erythrocyte cell number ( J:211773 )

IMPC - TCP

decreased hematocrit ( J:211773 )

IMPC - TCP

decreased hemoglobin content ( J:211773 )

IMPC - TCP

decreased mean corpuscular hemoglobin ( J:211773 )

IMPC - TCP

decreased mean corpuscular volume ( J:211773 )

♂

IMPC - TCP

increased leukocyte cell number ( J:211773 )

IMPC - TCP

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

♀

IMPC - TCP

decreased circulating glucose level ( J:211773 )

IMPC - TCP

decreased fasting circulating glucose level ( J:211773 )

IMPC - TCP

decreased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - TCP

decreased circulating triglyceride level ( J:211773 )

IMPC - TCP

increased circulating potassium level ( J:211773 )

♀

IMPC - TCP

increased circulating alanine transaminase level ( J:211773 )

♂

IMPC - TCP

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - TCP

increased circulating aspartate transaminase level ( J:211773 )

♂

IMPC - TCP

improved glucose tolerance ( J:211773 )

IMPC - TCP

immune system

enlarged spleen ( J:211773 )

♀

IMPC - TCP

increased leukocyte cell number ( J:211773 )

IMPC - TCP

limbs/digits/tail

long tibia ( J:211773 )

♂

IMPC - TCP

liver/biliary system

abnormal liver morphology ( J:211773 )

IMPC - TCP

nervous system

decreased prepulse inhibition ( J:211773 )

IMPC - TCP

renal/urinary system

polycystic kidney ( J:211773 )

IMPC - TCP

enlarged kidney ( J:211773 )

♂

IMPC - TCP

enlarged urinary bladder ( J:211773 )

♂

IMPC - TCP

reproductive system

small seminal vesicle ( J:211773 )

♂

IMPC - TCP

abnormal epididymis morphology ( J:211773 )

♂

IMPC - TCP

skeleton

long tibia ( J:211773 )

♂

IMPC - TCP

abnormal bone structure ( J:211773 )

♀

IMPC - TCP

decreased bone mineral content ( J:211773 )

IMPC - TCP

decreased bone mineral density ( J:211773 )

IMPC - TCP

vision/eye

abnormal eye morphology ( J:211773 )

♂

IMPC - TCP

cornea opacity ( J:211773 )

IMPC - TCP

abnormal retina morphology ( J:211773 )

♂

IMPC - TCP

abnormal retina vasculature morphology ( J:211773 )

IMPC - TCP

abnormal retina blood vessel morphology ( J:211773 )

IMPC - TCP

anophthalmia ( J:211773 )

♀

IMPC - TCP