Phenotypes associated with this allele

• Allele Symbol: Polr1b^em1(IMPC)Tcp
• Allele Name: endonuclease-mediated mutation 1, The Centre for Phenogenomics
• Allele ID: MGI:6156451
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polr1b^em1(IMPC)Tcp/Polr1b^em1(IMPC)Tcp	C57BL/6NCrl-Polr1b^em1(IMPC)Tcp/Tcp	MGI:6263202
ht2	Polr1b^em1(IMPC)Tcp/Polr1b^+	C57BL/6NCrl-Polr1b^em1(IMPC)Tcp/Tcp	MGI:6461547

Genotype
MGI:6263202

hm1

• Allelic Composition: Polr1b^em1(IMPC)Tcp/Polr1b^em1(IMPC)Tcp
• Genetic Background: C57BL/6NCrl-Polr1b^em1(IMPC)Tcp/Tcp

Data Sources

IMPC Data for Polr1b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - TCP

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

preweaning lethality, complete penetrance ( J:211773 )

IMPC - TCP

Genotype
MGI:6461547

ht2

• Allelic Composition: Polr1b^em1(IMPC)Tcp/Polr1b⁺
• Genetic Background: C57BL/6NCrl-Polr1b^em1(IMPC)Tcp/Tcp

Data Sources

IMPC Data for Polr1b

craniofacial

abnormal tooth morphology ( J:211773 )

IMPC - TCP

endocrine/exocrine glands

enlarged thymus ( J:211773 )

IMPC - TCP

growth/size/body

abnormal tooth morphology ( J:211773 )

IMPC - TCP

enlarged kidney ( J:211773 )

♂

IMPC - TCP

enlarged urinary bladder ( J:211773 )

♂

IMPC - TCP

hematopoietic system

enlarged thymus ( J:211773 )

IMPC - TCP

immune system

enlarged thymus ( J:211773 )

IMPC - TCP

enlarged lymph nodes ( J:211773 )

♂

IMPC - TCP

integument

thick skin ( J:211773 )

♂

IMPC - TCP

liver/biliary system

abnormal liver morphology ( J:211773 )

♂

IMPC - TCP

renal/urinary system

enlarged kidney ( J:211773 )

♂

IMPC - TCP

enlarged urinary bladder ( J:211773 )

♂

IMPC - TCP

skeleton

abnormal tooth morphology ( J:211773 )

IMPC - TCP