Phenotypes associated with this allele

• Allele Symbol: Pikfyve^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6156635
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lyz2^tm1(cre)Ifo/Lyz2^+ Pikfyve^tm1b(EUCOMM)Hmgu/Pikfyve^tm1b(EUCOMM)Hmgu	involves: 129P2/OlaHsd * C57BL/6N	MGI:6156769

Genotype
MGI:6156769

cn1

• Allelic Composition: Lyz2^tm1(cre)Ifo/Lyz2⁺; Pikfyve^{tm1b(EUCOMM)Hmgu}/Pikfyve^{tm1b(EUCOMM)Hmgu}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:244776 )

N • mice exhibit normal neutrophil and monocyte population as well as LPS-induced IL6 production

increased eosinophil cell number ( J:244776 )

• in house-dust mite-exposed mice

• however, treatment with retinoic acid restores numbers

decreased regulatory T cell number ( J:244776 )

• in the lungs of house-dust mite-exposed mice

• however, treatment with retinoic acid restores numbers

abnormal alveolar macrophage morphology ( J:244776 )

• partially retarded development

decreased alveolar macrophage number ( J:244776 )

• reduced CD11c^high and Siglec-F^high alveolar macrophages in bronchoalveolar lavage fluid and lungs

increased susceptibility to type I hypersensitivity reaction ( J:244776 )

• house-dust mite-exposed mice exhibit exacerbated inflammation with increased IL4 and IL13, increased eosinophils, and decreased regulatory T cells in the lungs compared with wild-type mice

• however, the numbers of dendritic cells and interstitial macrophages are normal

increased interleukin-13 secretion ( J:244776 )

• in the lung tissue of house-dust mite-exposed mice

increased interleukin-4 secretion ( J:244776 )

• in the lung tissue of house-dust mite-exposed mice

respiratory system

abnormal alveolar macrophage morphology ( J:244776 )

• partially retarded development

decreased alveolar macrophage number ( J:244776 )

• reduced CD11c^high and Siglec-F^high alveolar macrophages in bronchoalveolar lavage fluid and lungs

abnormal alveolar macrophage physiology ( J:244776 )

• reduced phagocytosis of ovalbumin protein

hematopoietic system

increased eosinophil cell number ( J:244776 )

• in house-dust mite-exposed mice

• however, treatment with retinoic acid restores numbers

decreased regulatory T cell number ( J:244776 )

• in the lungs of house-dust mite-exposed mice

• however, treatment with retinoic acid restores numbers

abnormal alveolar macrophage morphology ( J:244776 )

• partially retarded development

decreased alveolar macrophage number ( J:244776 )

• reduced CD11c^high and Siglec-F^high alveolar macrophages in bronchoalveolar lavage fluid and lungs