Phenotypes associated with this allele

• Allele Symbol: Eprs1^tm1.1Xen
• Allele Name: targeted mutation 1.1, Taconic Biosciences
• Allele ID: MGI:6156792
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eprs1^tm1.1Xen/Eprs1^tm1.1Xen	C57BL/6-Eprs1^tm1.1Xen	MGI:6157354

Genotype
MGI:6157354

hm1

• Allelic Composition: Eprs1^tm1.1Xen/Eprs1^tm1.1Xen
• Genetic Background: C57BL/6-Eprs1^tm1.1Xen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

extended life span ( J:244749 )

• average lifespan is 118 (an 18% increase compared with wild-type)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:244749 )

N • mice exhibit normal serum levels of glucose, triglycerides and fatty acids

increased fatty acid beta-oxidation ( J:244749 )

increased energy expenditure ( J:244749 )

decreased susceptibility to diet-induced obesity ( J:244749 )

• in mice fed high-fat diet

increased carbon dioxide production ( J:244749 )

• in the light and dark phases

increased oxygen consumption ( J:244749 )

• in the light and dark phases

impaired glucose tolerance ( J:244749 )

• slower glucose clearance following bolus injection of glucose in young mice

• however, older mice exhibit metabolism glucose quickly

increased insulin sensitivity ( J:244749 )

• faster glucose clearance following insulin injection in young mice

enhanced lipolysis ( J:244749 )

adipose tissue

decreased brown adipose tissue amount ( J:244749 )

• in the abdominal cavity

decreased abdominal adipose tissue amount ( J:244749 )

decreased white fat cell size ( J:244749 )

• with unaltered numbers

abnormal adipose tissue physiology ( J:244749 )

• reduced insulin-stimulated long chain fatty acid uptake

growth/size/body

decreased body weight ( J:244749 )

• in female and male mice beginning at 8 to 10 weeks

decreased susceptibility to diet-induced obesity ( J:244749 )

• in mice fed high-fat diet

cellular

increased fatty acid beta-oxidation ( J:244749 )