Analysis Tools
mortality/aging
cellular
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• E18.5 brains show severe impairment of axonal elongation of cortical commissural axons
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• neurons exhibit migration defects to layers II-IV of cerebral cortices at E18.5
• however, mice show normal gross morphology and histology of brains and no difference in the rate of the cell cycle exit in the developing cerebral cortices or thickness of the ventricular zone compared to controls
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nervous system
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• E18.5 brains show severe impairment of axonal elongation of cortical commissural axons
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• neurons exhibit migration defects to layers II-IV of cerebral cortices at E18.5
• however, mice show normal gross morphology and histology of brains and no difference in the rate of the cell cycle exit in the developing cerebral cortices or thickness of the ventricular zone compared to controls
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• cortical neurons isolated from E16.5 mutants and cultured in dissociated cell culture exhibit reduced length and branch number of putative axons and dendrites, indicating impaired neuritogenesis
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