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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxw7tm1Iken
targeted mutation 1, Tsuneo Ikenoue
MGI:6157075
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fbxw7tm1Iken/Fbxw7+
Krastm4Tyj/Kras+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA MGI:6157295
cn2
 		Fbxw7tm1Iken/Fbxw7tm1Iken
Krastm4Tyj/Kras+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA MGI:6157296
cn3
 		Fbxw7tm1Iken/Fbxw7tm1Iken
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * C57BL/6N * DBA MGI:6157293


Genotype
MGI:6157295
cn1
Allelic
Composition		 Fbxw7tm1Iken/Fbxw7+
Krastm4Tyj/Kras+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Iken mutation (0 available); any Fbxw7 mutation (84 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
bile duct hyperplasia ( J:258194 )
• bile duct hyperplasia is seen in some mice at 8 months of age
dilated bile duct ( J:258194 )
• bile duct dilation is seen in some mice at 8 months of age

liver/biliary system
bile duct hyperplasia ( J:258194 )
• bile duct hyperplasia is seen in some mice at 8 months of age
dilated bile duct ( J:258194 )
• bile duct dilation is seen in some mice at 8 months of age




Genotype
MGI:6157296
cn2
Allelic
Composition		 Fbxw7tm1Iken/Fbxw7tm1Iken
Krastm4Tyj/Kras+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Iken mutation (0 available); any Fbxw7 mutation (84 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased cholangiocarcinoma incidence ( J:258194 )
• all mice develop cholangiocarcinoma-like lesions composed of dysplastic dust-like structures surrounded by fibrosis within 2 months of birth

neoplasm
increased cholangiocarcinoma incidence ( J:258194 )
• all mice develop cholangiocarcinoma-like lesions composed of dysplastic dust-like structures surrounded by fibrosis within 2 months of birth

endocrine/exocrine glands
increased cholangiocarcinoma incidence ( J:258194 )
• all mice develop cholangiocarcinoma-like lesions composed of dysplastic dust-like structures surrounded by fibrosis within 2 months of birth




Genotype
MGI:6157293
cn3
Allelic
Composition		 Fbxw7tm1Iken/Fbxw7tm1Iken
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Iken mutation (0 available); any Fbxw7 mutation (84 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
bile duct hyperplasia ( J:258194 )
• hyperplasia of bile ducts throughout the liver at 12 months of age
dilated bile duct ( J:258194 )
• dilatation of bile ducts throughout the liver at 12 months of age

liver/biliary system
bile duct hyperplasia ( J:258194 )
• hyperplasia of bile ducts throughout the liver at 12 months of age
dilated bile duct ( J:258194 )
• dilatation of bile ducts throughout the liver at 12 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory