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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fbxw7tm1.1Iken
targeted mutation 1.1, Tsuneo Ikenoue
MGI:6157076
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Fbxw7tm1.1Iken/Fbxw7+ involves: C57BL/6 * C57BL/6N MGI:6157077


Genotype
MGI:6157077
ht1
Allelic
Composition
Fbxw7tm1.1Iken/Fbxw7+
Genetic
Background
involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1.1Iken mutation (0 available); any Fbxw7 mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no living newborns are obtained, however normal ratios of E18.5 embryos are seen, indicating that mutants die around birth

respiratory system
• alveolar septa are thickened at E18.5
• increase in the number of proliferating cells (Ki67+) in the lung
• aerated lung areas are small and alveolar septa are thickened at E18.5, suggesting respiratory failure as cause of perinatal lethality

craniofacial
• 1.3% of mutants exhibit cleft palate

digestive/alimentary system
• 1.3% of mutants exhibit cleft palate

growth/size/body
• 1.3% of mutants exhibit cleft palate

vision/eye
• 17% of mutants exhibit eyes open at birth





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory