mortality/aging
• no living newborns are obtained, however normal ratios of E18.5 embryos are seen, indicating that mutants die around birth
|
respiratory system
• alveolar septa are thickened at E18.5
|
• increase in the number of proliferating cells (Ki67+) in the lung
|
• aerated lung areas are small and alveolar septa are thickened at E18.5, suggesting respiratory failure as cause of perinatal lethality
|
craniofacial
cleft palate
(
J:258194
)
• 1.3% of mutants exhibit cleft palate
|
digestive/alimentary system
cleft palate
(
J:258194
)
• 1.3% of mutants exhibit cleft palate
|
growth/size/body
cleft palate
(
J:258194
)
• 1.3% of mutants exhibit cleft palate
|
vision/eye
• 17% of mutants exhibit eyes open at birth
|