About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fbxw7tm1.1Iken
targeted mutation 1.1, Tsuneo Ikenoue
MGI:6157076
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Fbxw7tm1.1Iken/Fbxw7+ involves: C57BL/6 * C57BL/6N MGI:6157077


Genotype
MGI:6157077
ht1
Allelic
Composition
Fbxw7tm1.1Iken/Fbxw7+
Genetic
Background
involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1.1Iken mutation (0 available); any Fbxw7 mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no living newborns are obtained, however normal ratios of E18.5 embryos are seen, indicating that mutants die around birth

respiratory system
• alveolar septa are thickened at E18.5
• increase in the number of proliferating cells (Ki67+) in the lung
• aerated lung areas are small and alveolar septa are thickened at E18.5, suggesting respiratory failure as cause of perinatal lethality

craniofacial
• 1.3% of mutants exhibit cleft palate

digestive/alimentary system
• 1.3% of mutants exhibit cleft palate

growth/size/body
• 1.3% of mutants exhibit cleft palate

vision/eye
• 17% of mutants exhibit eyes open at birth





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory