Phenotypes associated with this allele

• Allele Symbol: Dnajc13^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6157328
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnajc13^em1(IMPC)J/Dnajc13^em1(IMPC)J	C57BL/6NJ-Dnajc13^em1(IMPC)J/Mmjax	MGI:6492805
ht2	Dnajc13^em1(IMPC)J/Dnajc13^+	C57BL/6NJ-Dnajc13^em1(IMPC)J/Mmjax	MGI:6492804

Genotype
MGI:6492805

hm1

• Allelic Composition: Dnajc13^em1(IMPC)J/Dnajc13^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Dnajc13^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Dnajc13

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dnajc13^em1(IMPC)J/Dnajc13^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form outgrowths.

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• although blastocysts are present in approximate Mendelian ratios at E3.5 (36% versus expected 25%, n=14), no homozygous embryos are recovered at E7.5; excess resorption sites suggest that embryos elicit a decidual response in vivo

• in vitro, blastocysts do hatch from the zona pellucida and form outgrowths after 3 days in culture

Genotype
MGI:6492804

ht2

• Allelic Composition: Dnajc13^em1(IMPC)J/Dnajc13⁺
• Genetic Background: C57BL/6NJ-Dnajc13^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Dnajc13

cardiovascular system

decreased heart rate ( J:211773 )

IMPC - JAX

hematopoietic system

decreased mean corpuscular hemoglobin ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

♂

IMPC - JAX