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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Notch2tm2.2Ecan
targeted mutation 2.2, Ernesto Canalis
MGI:6157623
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Notch2tm2.2Ecan/Notch2+ involves: 129S1/Sv * C57BL/6J MGI:6157629


Genotype
MGI:6157629
ht1
Allelic
Composition
Notch2tm2.2Ecan/Notch2+
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2tm2.2Ecan mutation (0 available); any Notch2 mutation (99 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• femurs are smaller, with total area, bone area, and periosteal and endocortical perimeters reduced
• males exhibit a small approximate 5% reduction in femoral length
• mice exhibit osteopenia
• mice exhibit a porous cortical bone
• decrease in femoral midshaft cortical bone volume
• mice exhibit a thin cortical bone
• mice exhibit a 50% decrease in trabecular bone volume secondary to a reduced number and thickness of trabeculae
• connectivity density is lower and structure model index is higher, indicating prevelance of rod-like trabeculae
• increase in trabecular separation

limbs/digits/tail
• femurs are smaller, with total area, bone area, and periosteal and endocortical perimeters reduced
• males exhibit a small approximate 5% reduction in femoral length

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Hajdu-Cheney syndrome DOID:2736 OMIM:102500
J:246017





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory