Phenotypes associated with this allele

• Allele Symbol: Armc5^tm1Stra
• Allele Name: targeted mutation 1, Constantine A Stratakis
• Allele ID: MGI:6157645
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Armc5^tm1Stra/Armc5^tm1Stra	involves: 129 * C57BL/6N * Swiss	MGI:6157871
ht2	Armc5^tm1Stra/Armc5^+	involves: 129 * C57BL/6N * Swiss	MGI:6157872

Genotype
MGI:6157871

hm1

• Allelic Composition: Armc5^tm1Stra/Armc5^tm1Stra
• Genetic Background: involves: 129 * C57BL/6N * Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:244906 )

• nearly no mice are present at weaning and fewer than expected mice are born

embryonic lethality, incomplete penetrance ( J:244906 )

• despite being present in normal numbers between E6.5 and E8.5, fewer than expected mice are present at E13.5

embryo

failure to gastrulate ( J:244906 )

• in mice that do not survive embryogenesis

absent mesoderm ( J:244906 )

• in mice that do not survive embryogenesis

growth/size/body

decreased body size ( J:244906 )

• at weaning in surviving female and male mice

decreased body weight ( J:244906 )

• at weaning in surviving female and male mice

Genotype
MGI:6157872

ht2

• Allelic Composition: Armc5^tm1Stra/Armc5⁺
• Genetic Background: involves: 129 * C57BL/6N * Swiss

endocrine/exocrine glands

abnormal adrenal cortex morphology ( J:244906 )

• at 12 months, 4 of 8 mice (increasing to 4 of 6 mice by 18 months of age) exhibit invasion of fibroblastic-like cells originating from the capsule with accumulation of eosinophilic cells unlike in wild-type mice

abnormal adrenal gland zona fasciculata morphology ( J:244906 )

• accumulation of lipids in the zona fasciculata cells with disrupted mitochondrial cristae and an increase of lysosomes

thin adrenal cortex ( J:244906 )

homeostasis/metabolism

decreased circulating corticosterone level ( J:244906 )

• 2-fold at 12, but not 9, months

increased circulating corticosterone level ( J:244906 )

• between 12 and 18 months

increased adrenocorticotropin level ( J:244906 )

• at 9 and 12 months