All Phenotypes Map2k1<tm2.1Chrn> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Map2k1^tm2.1Chrn
targeted mutation 2.1, M Jean Charron
MGI:6157680

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map2k1^tm2.1Chrn/Map2k1^tm2.1Chrn	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J	MGI:6159581
ht2	Map2k1^tm2.1Chrn/Map2k1⁺	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J	MGI:6159580
ht3	Map2k1^tm2.1Chrn/Map2k1^tm1.1Chrn	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J	MGI:6159582

Allelic Composition	Map2k1^tm2.1Chrn/Map2k1^tm2.1Chrn
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1^tm2.1Chrn mutation (1 available); any Map2k1 mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pulmonary artery stenosis ( J:261678 )

• pulmonary artery stenosis is observed at E13.5

• left and right pulmonary artery lumen areas are reduced

craniofacial

increased cranium length ( J:261678 )

nervous system

increased astrocyte number ( J:261678 )

• increased density of GFAP+ astrocytes is found in sensory cortices and hippocampal CA1

increased oligodendrocyte number ( J:261678 )

• increased density of oligodendrocytes in the sensory cortex

skeleton

increased cranium length ( J:261678 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cardiofaciocutaneous syndrome		DOID:0060233	OMIM:PS115150	J:261678

Allelic Composition	Map2k1^tm2.1Chrn/Map2k1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1^tm2.1Chrn mutation (1 available); any Map2k1 mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pulmonary artery stenosis ( J:261678 )

• pulmonary artery stenosis is observed at E13.5 left

• left and right pulmonary artery lumen areas are reduced

Allelic Composition	Map2k1^tm2.1Chrn/Map2k1^tm1.1Chrn
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1^tm1.1Chrn mutation (0 available); any Map2k1 mutation (94 available)
Map2k1^tm2.1Chrn mutation (1 available); any Map2k1 mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

pulmonary artery stenosis ( J:261678 )

• pulmonary artery stenosis is observed at E13.5

• left and right pulmonary artery lumen areas are reduced

craniofacial

decreased cranium length ( J:261678 )

decreased cranium width ( J:261678 )

skeleton

decreased cranium length ( J:261678 )

decreased cranium width ( J:261678 )

vision/eye

increased inner canthal distance ( J:261678 )

• width of the inner canthal distance is increased

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24