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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Igsf8tm1.2Osb
targeted mutation 1.2, Research Institute for Microbial Diseases, Osaka University
MGI:6157961
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Igsf8tm1.2Osb/Igsf8tm1.2Osb involves: 129S2/SvPas * C57BL/6J MGI:6159882
ht2
Igsf8tm1.1Osb/Igsf8tm1.2Osb involves: 129S2/SvPas * C57BL/6J MGI:6159881


Genotype
MGI:6159882
hm1
Allelic
Composition
Igsf8tm1.2Osb/Igsf8tm1.2Osb
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igsf8tm1.2Osb mutation (0 available); any Igsf8 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• surprisingly, females are healthy and exhibit no fertilization defect in vitro or in vivo
• eggs are morphologically normal and show no defects in plasma membrane binding or the sperm-egg fusion step
• eggs retain normal protein levels and localization of CD9 on their surface, resulting in normal microvilli formation




Genotype
MGI:6159881
ht2
Allelic
Composition
Igsf8tm1.1Osb/Igsf8tm1.2Osb
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igsf8tm1.1Osb mutation (1 available); any Igsf8 mutation (26 available)
Igsf8tm1.2Osb mutation (0 available); any Igsf8 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• normal fertility and egg morphology with no detectable defects in plasma membrane binding or sperm-egg fusion, as shown by in vitro sperm-egg fusion assays





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory