Phenotypes associated with this allele

• Allele Symbol: 9630013A20Rik^em1Qrlu
• Allele Name: endonuclease-mediated mutation 1, Q Richard Lu
• Allele ID: MGI:6158415
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	9630013A20Rik^em1Qrlu/9630013A20Rik^em1Qrlu	Not Specified	MGI:6158439

Genotype
MGI:6158439

hm1

• Allelic Composition: 9630013A20Rik^em1Qrlu/9630013A20Rik^em1Qrlu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:256017 )

N • number of Pdgfra+ oligodendrocyte progenitor cells in brain and spinal cord

abnormal oligodendrocyte morphology ( J:256017 )

• lower percentage of CC1+ differentiating oligodendrocytes amongst Olig2+ oligodendrocytes in spinal cord at age P1

• lower number of Mbp+ mature oligodendrocytes in brain at age P6

dysmyelination ( J:256017 )

• lack of myelination of axons in optic nerves at age P9

• reduced myelination of axons in optic nerves at age P17

• thinner myelin sheaths around axons of optic nerve at age P17

• reduced myelination of axons 14 days after experimental demyelination in spinal white matter at age P60

• thinner myelin sheaths around axons 14 days after experimental demyelination in spinal white matter at age P60

• myelination of axons in optic nerves of adult mice (age P60)