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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nlgn2tm1.1Gchn
targeted mutation 1.1, Gong Chen
MGI:6158645
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nlgn2tm1.1Gchn/Nlgn2tm1.1Gchn involves: 129S/SvEv * C57BL/6J MGI:6294898


Genotype
MGI:6294898
hm1
Allelic
Composition
Nlgn2tm1.1Gchn/Nlgn2tm1.1Gchn
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn2tm1.1Gchn mutation (1 available); any Nlgn2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the contextual fear conditioning test, mice are capable of associating the conditioning chamber with foot-shock in the initial training but they fail to retain the fear context memory in the following days of testing, indicating impaired hippocampal dependent cognitive function
• mice show reduced spontaneous alternation in the Y maze, indicating a working memory dysfunction
• in an acute stress test in which mice are placed into restraining tubes for 1 hour, mutants struggle more intensively for a long time and excrete more than wild-type mice
• mice spend less time in the center region during an open field test, although the total distance traveled is similar to wild-type mice
• in the elevated plus maze test, mice spend less time in the open arm than wild-type mice, while the total travel distance is similar to wild-type mice
• mice show a reduction of freezing time in the forced swim test indicating hyperactivity induced by acute stress
• mice show a reduction in the startle response when stimulated at 100-120 dB
• mice show a reduction of freezing time in the forced swim test indicating hyperactivity induced by acute stress

homeostasis/metabolism
• mice show a much higher level of corticosterone after restraining in the acute stress test, indicating a hyperactive hypothalamic-pituitary-adrenal axis response towards stress

nervous system
• mice show a reduction in GABAergic synapse density, with a decrease of postsynaptic GABA(A) receptor gamma2 subunit and the scaffold protein gephyrin around cell soma in hippocampal regions and reduced parvalbumin+ and vesicular GABA transporter (vGAT)+ puncta number and size in the dentate granule cells and CA1/CA3 pyramidal cells
• mice show a decrease of cFos-positive cells in the dentate gyrus and CA2/3 regions of the hippocampus after stress indicating impaired hippocampal activation toward acute stress
• both the frequency and amplitude of miniature inhibitory postsynaptic currents (mIPSCs) are decreased in dentate granule cells indicating impaired GABAergic neurotransmission
• however, no change is seen in miniature excitatory postsynaptic currents (mEPSCs) in dentate granule cells
• pre-pulse inhibition is impaired

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
J:272181





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory